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Reply to Hasle et al

Leukemia volume 17, pages 2531–2532 (2003)Cite this article

TO THE EDITOR

We read with great interest the article by Hasle et al1 regarding the pediatric approach to the World Health Organization (WHO) classification of myelodysplastic syndromes (MDSs). Since MDS in children differs from those seen in adults clinically and biologically, and approximately 40% of the pediatric MDS cases cannot be classified by adult classifications such as the French–American–British classification; the author correctly emphasizes the need for a clear and useful classification for these disorders in childhood. However, the new classification did not differentiate between pediatric MDS and pediatric myeloproliferative syndromes (MPSs). This is a great challenge since some of these chronic myeloid disorders are myeloproliferative rather than myelodysplastic.

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References

  1. Hasle H, Niemeyer CM, Chessells JM, Baumann I, Benett JM, Kerndrup G et al. A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative diseases. Leukemia 2003; 17: 277–282.

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  2. Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J et al. The World Health Organization classification of hematological malignancies report of the clinical advisory committee meeting, Airlie House, Virginia, November 1997. Mod Pathol 2000; 13: 193–207.

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  3. Mandel K, Dror Y, Poon A, Freedman MH . A practical, comprehensive classification for pediatric myelodysplastic syndromes: the CCC System. J Pediatr Hematol Oncol 2002; 24: 596–605.

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Authors and Affiliations

  1. Division of Haematology/Oncology, Department of Paediatrics, University of Toronto, The Hospital for Sick Children, Toronto, Canada

    A Gassas, M H Freedman, K Mandel & Y Dror

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  1. A Gassas
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  2. M H Freedman
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  3. K Mandel
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  4. Y Dror
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Gassas, A., Freedman, M., Mandel, K. et al. Reply to Hasle et al. Leukemia 17, 2531–2532 (2003). https://doi.org/10.1038/sj.leu.2403165

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  • DOI: https://doi.org/10.1038/sj.leu.2403165

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