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MLL partial tandem duplications in acute leukemia cell lines

Leukemia volume 17, pages 980–981 (2003)Cite this article

TO THE EDITOR

Since there has been no report of cell lines carrying MLL PTD, we set out to screen a panel of cell lines (66 AML, 73 ALL) for this mutation. The ALL-derived cell lines were included, although to our knowledge no ALL cases with MLL PTD have yet been described. However, the MLL BCR is affected by both translocations and PTD, and MLL translocations are common not only in AML but also in ALL.1,3 Therefore, we reasoned that ALL-derived cell lines might also carry the MLL PTD.

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Acknowledgements

We thank Dr Susanne Schnittger (University of Munich, Germany) for providing MLL PTD cDNA as positive control.

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  1. Department of Human and Animal Cell Cultures, DSMZ – German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany

    H Quentmeier, J Reinhardt, M Zaborski & H G Drexler

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  1. H Quentmeier
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  2. J Reinhardt
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  4. H G Drexler
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Quentmeier, H., Reinhardt, J., Zaborski, M. et al. MLL partial tandem duplications in acute leukemia cell lines. Leukemia 17, 980–981 (2003). https://doi.org/10.1038/sj.leu.2402911

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