Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23)

Leukemia volume 17, pages 637–641 (2003)Cite this article

TO THE EDITOR

Chromosomal abnormalities involving the Mixed Lineage Leukemia (MLL) gene at 11q23 are among the most frequent cytogenetic findings in acute myeloid leukemia (AML).1 The t(10;11)(q22;q23) has been reported in several cases of AML;2,3,4,5 however, the genes involved in this translocation have not been identified. Here, we have cloned the derivative chromosome 11 breakpoint in a case of AML containing this translocation using long-distance inverse-polymerase chain reaction (LDI-PCR) and identified the partner gene as TET1, which is identical to the recently cloned gene, LCX.5 Importantly, TET1 appears to be a member of a novel, well-conserved protein family of unknown biologic function.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3
Figure 4

References

  1. Ayton PM, Cleary ML . Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins. Oncogene 2001; 20: 5695–5707.

    Article  CAS  Google Scholar 

  2. Aventin A, La Starza R, Martinez C, Wlodarska I, Boogaerts M, Van den Berghe H et al. Involvement of MLL gene in a t(10;11)(q22;q23) and a t(8;11)(q24;q23) identified by fluorescence in situ hybridization. Cancer Genet Cytogenet 1999; 108: 48–52.

    Article  CAS  Google Scholar 

  3. Harrison CJ, Cuneo A, Clark R, Johansson B, Lafage-Pochitaloff M, Mugneret F et al. Ten novel 11q23 chromosomal partner sites. European 11q23 Workshop participants. Leukemia 1998; 12: 811–822.

    Article  CAS  Google Scholar 

  4. Thirman MJ, Gill HJ, Burnett RC, Mbangkollo D, McCabe NR, Kobayashi H et al. Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. N Engl J Med 1993; 329: 909–914.

    Article  CAS  Google Scholar 

  5. Ono R, Taki T, Taketani T, Taniwaki M, Kobayashi H, Hayashi Y . LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23). Cancer Res 2002; 62: 4075–4080.

    CAS  PubMed  Google Scholar 

  6. Mathew S, Behm F, Dalton J, Raimondi S . Comparison of cytogenetics Southern blotting and fluorescence in situ hybridization as methods for detecting MLL gene rearrangements in children with acute leukemia and with 11q23 abnormalities. Leukemia 1999; 13: 1713–1720.

    Article  CAS  Google Scholar 

  7. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ . Basic local alignment search tool. J Mol Biol 1990; 215: 403–410.

    Article  CAS  Google Scholar 

  8. Thompson JD, Higgins DG, Gibson TJ . CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 1994; 22: 4673–4680.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank Drs S Morris, J Hess, S Shurtleff, B Sorrentino and S Hanissian for reagents and helpful advice, and acknowledge Drs C Mecucci and A Aventin, and Ms P Talley for providing cytogenetic samples. This work was supported in part by an NIH Cancer Center CORE grant CA21765 and by the American Lebanese and Syrian Associated Charities (ALSAC) of St Jude Children's Research Hospital.

Author information

Authors and Affiliations

  1. Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA

    R B Lorsbach, J Moore, S Mathew, S C Raimondi & J R Downing

  2. Hartwell Center for Bioinformatics and Biotechnology, St. Jude Children's Research Hospital, Memphis, TN, USA

    S T Mukatira

  3. Department of Pathology, University of Tennessee, College of Medicine, Memphis, TN, USA

    R B Lorsbach, S C Raimondi & J R Downing

Authors
  1. R B Lorsbach
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J Moore
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S Mathew
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S C Raimondi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S T Mukatira
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. J R Downing
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lorsbach, R., Moore, J., Mathew, S. et al. TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23). Leukemia 17, 637–641 (2003). https://doi.org/10.1038/sj.leu.2402834

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2402834

This article is cited by

Search

Advanced search

Quick links