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VLA-4 affinity correlates with peripheral blood white cell count and DNA content in patients with precursor B-ALL

Leukemia volume 17, pages 641–643 (2003)Cite this article

A Corrigendum to this article was published on 10 March 2010

TO THE EDITOR

We have recently completed a study that suggests affinity state measurements may be a useful tool in studies of acute leukemia pathogenesis. Cellular adhesion molecules such as VLA-4 (very late antigen-4; CD49d/CD29) play an important role in the survival of normal and leukemic B cells.1,2 mAb to VLA-4 inhibits lymphopoiesis,1 and the binding of VLA-4 on precursor B-ALL cells to its ligand vascular cell adhesion molecule-1 (VCAM-1) on BM stromal cells is required for leukemic cell survival.2,3 Defective VLA-4-dependent adhesion has also been identified in a subset of precursor B-ALL cases.3 Yet, the clinical and biologic significance, if any, to defective VLA-4-mediated adhesion on precursor B-ALL cells is unknown.

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  1. University of New Mexico, Albuquerque, NM, USA

    A M Blenc, A Chiagev, L Sklar & R S Larson

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  1. A M Blenc
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  2. A Chiagev
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  3. L Sklar
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  4. R S Larson
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Blenc, A., Chiagev, A., Sklar, L. et al. VLA-4 affinity correlates with peripheral blood white cell count and DNA content in patients with precursor B-ALL. Leukemia 17, 641–643 (2003). https://doi.org/10.1038/sj.leu.2402827

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