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Distinct genomic events in the myeloid and lymphoid lineages in simultaneous presentation of chronic myeloid leukemia and B-chronic lymphocytic leukemia

Leukemia volume 16, pages 955–956 (2002)Cite this article

Deranged B-lymphopoiesis in chronic myeloid leukemia (CML) is a rare event arising questions about the cell(s) of origin and the existence of clonal instability. Occurrence of CML as second neoplasia in the course of chronic lymphocytic leukemia (CLL) and vice versa, before and after chemotherapy, have been reported. Sometimes, the presence of either a myelocytic or a lymphocytic clone has emerged concomitantly with a lymphoid (but not myeloid) blast transformation. Moreover, only five cases of simultaneous occurrence of CML and CLL in the same patient have been described. Whether the two disorders originate from the same or two different clonal cells has been investigated in very few cases by means of molecular studies (cited in Refs 1, 2 and 3).

We report here on the first patient with simultaneous CML and CLL evolved to myeloid blast crisis, in which the origin of the two cell lines was determined by means of molecular studies and immunophenotyping, combined to interphase hybridization techniques.

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References

  1. Esteve J, Cervantes F, Rives S, Rozman M, Zarco MA, Montserrat E . Simultaneous occurrence of B-cell chronic lymphocytic leukemia and chronic myeloid leukemia with further evolution to lymphoid blast crisis Haematologica 1997 82: 596–599

    CAS  PubMed  Google Scholar 

  2. Spencer A, Szydlo R, Grand FH, Goldman JM, Melo JV . Abnormal pattern of immunoglobulin heavy chain gene DNA fingerprinting during chronic phase of chronic myeloid leukemia Leuk Lymphoma 1999 32: 299–307

    Article  CAS  Google Scholar 

  3. Mossafa H, Fourcade C, Pulic M, Jary L, Cheze S, Szpiro-Tapia S, Troussard X . Chronic lymphocytic leukemia associated with myelodysplastic syndrome and/or chronic myeloid leukemia:evidence for independent clonal chromosomal evolution Leuk Lymphoma 2001 41: 337–341

    Article  CAS  Google Scholar 

  4. Weber-Matthiesen K, Winkemann M, Muller-Hermelink A, Schlegelberger B, Grote W . Simultaneous fluorescence immunophenotyping and interphase cytogenetics: a contribution to the characterization of tumor cells J Histochem Cytochem 1992 40: 171–175

    Article  CAS  Google Scholar 

  5. Emilia G, Marasca R, Zucchini P, Temperani P, Luppi M, Torelli G, Lanza F, De Angeli C, Gandini D, Castoldi GL, Vallisa D, Cavanna L, Del Senno L . BCR-ABL rearrangement is not detectable in essential thrombocythemia Blood 2001 97: 2187–2189

    Article  CAS  Google Scholar 

  6. Narni F, Colò A, Venturelli D, Selleri L, Tabilio A, Artusi T, Di Prisco AU, Torelli G, Torelli U . Immunoglobulin and T cell receptor beta chain gene rearrangement as lineage marker in human leukemias: a study of 78 cases Haematologica 1987 72: 391–397

    CAS  PubMed  Google Scholar 

  7. Donher H, Stilgenbauer S, Benner A, Leupolt E, Krober A, Bullinger L, Donher K, Bentz M, Lichter P . Genomic aberrations and survival in chronic lymphocytic leukemia N Engl J Med 2000 343: 1910–1916

    Article  Google Scholar 

  8. Gahn B, Wendenburg B, Troff C, Neef J, Grove D, Haferlach T, Hiddeman W, Wormann B . Analysis of progenitor cell involvement in B-CLL by simultaneous immunophenotypic and genotypic analysis at single cell level Br J Haematol 1999 105: 955–959

    Article  CAS  Google Scholar 

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Acknowledgements

CM was supported by AIRC, CNR, MURST, Italy and GE, PT and SS by MURST.

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Authors and Affiliations

  1. Hematology and Bone Marrow Transplantation Unit, University of Perugia, Italy

    B Crescenzi, R La Starza, C Matteucci, S Romoli, MF Martelli & C Mecucci

  2. Department of Medical Sciences, Section of Internal Medicine and Hematology, University of Modena and Reggio Emilia, Modena, Italy

    S Sacchi, R Marasca, P Temperani, G Bonacorsi & G Emilia

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  1. B Crescenzi
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  2. S Sacchi
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  3. R Marasca
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  10. C Mecucci
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  11. G Emilia
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Crescenzi, B., Sacchi, S., Marasca, R. et al. Distinct genomic events in the myeloid and lymphoid lineages in simultaneous presentation of chronic myeloid leukemia and B-chronic lymphocytic leukemia. Leukemia 16, 955–956 (2002). https://doi.org/10.1038/sj.leu.2402490

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