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Comment on ‘Functional disturbance of marrow stromal microenvironment in the myelodysplastic syndromes’ by S Tauro et al

Leukemia volume 16, pages 960–961 (2002)Cite this article

This commentary concerns the paper ‘Functional disturbance of marrow stromal microenvironment in the myelodysplastic syndromes’ by S Tauro et al in this issue of Leukemia 2002; 16: 785–790.

The bone marrow stroma is known to play an integral role in the development and maintenance of normal hematopoiesis. Imperatively, stromal abnormalities have been suspected to contribute to the pathobiology of bone marrow disorders with impaired hematopoiesis. Particularly, in myelodysplastic syndromes (MDS) the postulate of abnormal stroma has existed for over a decade. The difficulties in establishing stromal layers from bone marrow aspirate mononuclear cells (BMMNC) of MDS patients acknowledged by many workers in the field have restricted investigations on the role of stroma in MDS to a handful studies.1,2,3,4 It appears that the ability to form stromal layers in vitro may vary from patient to patient,3,5 with a sizeable number of patients retaining the ability to form normal grade stroma.1 Albeit inconsistent in type, most MDS stromal layers in vitro may demonstrate some hitherto incompletely characterized phenotypic and/or metabolic defects.2,3,6 Interestingly, in previous studies the cytokine profile elaborated by the MDS stroma established from BMMNC, however, appeared hardly any different from that of the normal control cultures.7,8,9 In line with these observations the hematopoietic growth supporting activity of the bone marrow stroma may be affected only in a subset of MDS patients.2,6,9,10

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  1. MDS Center and Section of Myeloid Diseases, Rush Cancer Institute, Chicago, IL, USA

    SD Mundle

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Mundle, S. Comment on ‘Functional disturbance of marrow stromal microenvironment in the myelodysplastic syndromes’ by S Tauro et al. Leukemia 16, 960–961 (2002). https://doi.org/10.1038/sj.leu.2402429

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