Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Correspondence
  • Published:

Regions of juxtaposition in unbalanced 1q rearrangements of malignant hemopathies

Leukemia volume 15, pages 861–863 (2001)Cite this article

Unbalanced rearrangements of 1q are widely reported in solid tumors, as well as in myeloid and lymphoid hematological malignancies. In a series of cases with heterogeneous karyotypes, the satellite II family emerged as a frequent site of recombination.1 We selected 11 cases of hematological malignancies with a similar karyotypic change due to a translocation between the whole long arm of chromosome 1 and the centromeric region of different partners. The aim of our investigation was to identify the site of juxtaposition of either chromosome 1q or the partner of translocation.

The partners for satellite II family of 1q were typically represented by centromeric or paracentromeric regions of different chromosomes. From our experiments, the last retained sequences of chromosome partners belonged to alphoid (cases 2 and 9) or NORs (cases 3 and 6) in the acrocentrics, to alphoid sequences in chromosome 12 (case 8), and to heterochromatin in chromosome 16 (case 7). Structural homologies might favor such recombinations between the 1q heterochromatin and centromeric or paracentromeric sites of other chromosomes. Similarities have been described between NORs and centromeric heterochromatin of chromosome 1.2 Moreover, homologous sequences, belonging to different beta-satellite subfamilies, have been located on the short arms of acrocentrics as well as within centromeric regions of chromosome 1 and 9.3

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

References

  1. Busson-Le Coniat M, Salomon-Nguyen F, Dastugue N, Maarek O, Lafage-Pochitaloff M, Mozziconacci M-J, Baranger L, Brizard F, Radford I, Jeanpierre M, Bernard OA, Berger R . Fluorescence in situ hybridization analysis of chromosome 1 abnormalities in hematopoietic disorders: rearrangements of DNA satellite II and new recurrent translocations Leukemia 1999 13: 1975–1981

    Article  CAS  Google Scholar 

  2. Pardo D, Luciani J-M, Stahl A . Localization, par hybridation in situ, des genes des ARN 28S et 18S dans les chromosomes somatiques humains Ann Genet 1975 18: 105–109

    CAS  PubMed  Google Scholar 

  3. Assum G, Fink T, Steinbesser T, Fisel KJ . Analysis of human extrachromosomal DNA elements originating from different beta-satellite subfamilies Hum Genet 1993 91: 489–495

    Article  CAS  Google Scholar 

  4. Hansen RS, Wijmenga C, Luo P, Stanek AM, Canfield TK, Weemaes CM, Gartler SM . The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome Proc Natl Acad Sci USA 1999 96: 14412–14417

    Article  CAS  Google Scholar 

  5. Sumner AT, Mitchell AR, Ellis PM . A FISH study of chromosome fusion un the ICF syndrome: involvement of paracentric heterochromatin but not of the centromeres themselves J Med Genet 1998 35: 833–835

    Article  CAS  Google Scholar 

  6. Qu G-Z, Grundy PE, Narayan A, Ehrlich M . Frequent hypomethylation in Wilms tumors of pericentric DNA in chromosomes 1 and 16 Cancer Genet Cytogenet 1999 109: 34–39

    Article  CAS  Google Scholar 

  7. Sawyer JR, Tricot G, Mattox S, Jagannath S, Barlogie B . Jumping translocations of chromosomes 1q in multiple myeloma: evidence for a mechanism involving decondansation of pericentromeric heterochromatin Blood 1998 91: 1732–1741

    CAS  PubMed  Google Scholar 

  8. Kokalj-Vokac N, Almeida A, Viegas-Pequignot E, Jeanpierre M, Malfoy B, Dutrillaux B . Specific induction of uncoiling and recombination by azacytidine in classical satellite-containing constitutive heterochromatin Cytogenet Cell Genet 1993 63: 11–15

    Article  CAS  Google Scholar 

Download references

Acknowledgements

CM is partially supported by AIRC (Associazione Italiana per la Ricerca sul Cancro) and MURST COFIN99.

Author information

Authors and Affiliations

  1. Hematology and Bone Marrow Transplantation Unit, University of Perugia, Italy

    R La Starza, D Falzetti, MF Martelli & C Mecucci

  2. Hematologia, Hospital San Pau, Barcelona

    A Aventin

  3. Center for Human Genetics, University of Leuven,

    I Wlodarska

  4. Unidad de Genetica, Lab a-205, Universidad Autonoma de Madrid,

    AM Fernandez Peralta & JJ Gonzalez-Aguilera

  5. Hematology Unit, University of Florence, Italy

    S Ciolli

Authors
  1. R La Starza
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Aventin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D Falzetti
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I Wlodarska
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. AM Fernandez Peralta
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. JJ Gonzalez-Aguilera
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. S Ciolli
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. MF Martelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. C Mecucci
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

La Starza, R., Aventin, A., Falzetti, D. et al. Regions of juxtaposition in unbalanced 1q rearrangements of malignant hemopathies. Leukemia 15, 861–863 (2001). https://doi.org/10.1038/sj.leu.2402100

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.leu.2402100

Search

Advanced search

Quick links