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Transcription factors and translocations in lymphoid and myeloid leukemia

Leukemia volume 15, pages 313–331 (2001)Cite this article

Abstract

Chromosomal translocations involving transcription factors and aberrant expression of transcription factors are frequently associated with leukemogenesis. Transcription factors are essential in maintaining the regulation of cell growth, development, and differentiation in the hematopoietic system. Alterations in the mechanisms that normally control these functions can lead to hematological malignancies. Further characterization of the molecular biology of leukemia will enhance our ability to develop disease-specific treatment strategies, and to develop effective methods of diagnosis and prognosis.

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Acknowledgements

We thank Patricia Mora-Garcia and Jorge Vargas for their suggestions and assistance in editing. This work was supported by National Institute of Health Grant CA68221-03 and American Cancer Society Grant RPG 99-081-01-LBC. KMS is a Scholar of the Leukemia and Lymphoma Society.

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  1. Division of Hematology-Oncology, Departments of Pediatrics, A2-412 MDCC, and Pathology and Laboratory Medicine, UCLA School of Medicine and Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA

    HN Crans & KM Sakamoto

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  1. HN Crans
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  2. KM Sakamoto
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Crans, H., Sakamoto, K. Transcription factors and translocations in lymphoid and myeloid leukemia. Leukemia 15, 313–331 (2001). https://doi.org/10.1038/sj.leu.2402033

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  • DOI: https://doi.org/10.1038/sj.leu.2402033

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