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Review

The most unkindest cut of all: on the multiple roles of mammalian caspases*

Leukemia volume 14, pages 1514–1525 (2000)Cite this article

Abstract

The caspases, first discovered almost a decade ago, are intracellular cysteine proteases which have been shown to play an esssential role in the initiation and execution phases of apoptotic cell death. Numerous strategies for the activation and inhibition of these ‘killer’ proteases have evolved, including the regulation of caspase expression and function at the transcriptional and post-translational level, as well as the expression of viral and cellular inhibitors of caspases. Emerging evidence in recent years has also implicated the caspases in various, non-apoptotic aspects of cellular physiology, such as cytokine processing during inflammation, differentiation of progenitor cells during erythropoiesis and lens fiber development, and proliferation of T lymphocytes, thus attesting to the pleiotropic functions of these proteases. The present review aims to discuss the multiple roles of the mammalian caspases with particular emphasis on their activation and regulation in cells of leukemic origin and the attendant possibilities of therapeutic intervention.

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Acknowledgements

These studies were supported by the Swedish Medical Research Foundation (SO, BZ, BF) and the Swedish Cancer Foundation (BZ). BF holds a combined clinical training and research position at the Karolinska Hospital and Karolinska Institutet.

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  1. Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

    B Fadeel, S Orrenius & B Zhivotovsky

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  1. B Fadeel
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  2. S Orrenius
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*From Julius Caesar (act III, scene 2) by William Shakespeare

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Fadeel, B., Orrenius, S. & Zhivotovsky, B. The most unkindest cut of all: on the multiple roles of mammalian caspases*. Leukemia 14, 1514–1525 (2000). https://doi.org/10.1038/sj.leu.2401871

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