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Acute Myeloid Leukemia

Clonality analysis of hematopoietic cell lineages in acute myeloid leukemia and translocation (8;21): only myeloid cells are part of the malignant clone

Leukemia volume 11, pages 202–205 (1997)Cite this article

An Erratum to this article was published on 01 June 1997

Abstract

Bone marrow from six patients with acute myeloid leukemia (AML) and t(8;21) (q22;q22) or a variant t(8;13;21) was studied by simultaneous analysis of cell morphology and karyotype. Combination of May–Grünwald–Giemsa (MGG) and fluorescence in situ hybridization (FISH) using probes specific for the breakpoint regions of chromosome 8 and 21 allowed us to establish the extent of cell-lineage involvement of the translocation. The translocation was found in all myeloid blasts and in high percentages of the more mature neutrophilic cells. In one patient we could demonstrate the translocation in the eosinophils as well. Erythroblasts and lymphocytes did not show the t(8;21) abnormality. These results indicate that the t(8;21) in AML is restricted to the myeloid (granulocytic) lineage.

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Authors and Affiliations

  1. Department of Hematology, University Hospital Rotterdam and Erasmus University Rotterdam, The Netherlands

    K van Lom, F Vandekerckhove & B Löwenberg

  2. Department of Cell Biology and Genetics, Erasmus University Rotterdam, The Netherlands

    A Hagemeijer

  3. Department of Hematology, University Hospital Rotterdam – Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

    GE de Greef

  4. Department of Biology and Genetics, School of Medicine, University of Milan, Italy

    N Sacchi

Authors
  1. K van Lom
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  2. A Hagemeijer
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  3. F Vandekerckhove
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  4. GE de Greef
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  5. N Sacchi
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  6. B Löwenberg
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van Lom, K., Hagemeijer, A., Vandekerckhove, F. et al. Clonality analysis of hematopoietic cell lineages in acute myeloid leukemia and translocation (8;21): only myeloid cells are part of the malignant clone. Leukemia 11, 202–205 (1997). https://doi.org/10.1038/sj.leu.2400544

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  • DOI: https://doi.org/10.1038/sj.leu.2400544

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