Abstract
The chromosomes of one or other of the “parents” of a hybrid cell are usually gradually lost over successive generations. X-irradiation, γ-irradiation or BUDR labelling of one “parent” before fusion can be used to predetermine which of the two sets of chromosomes will be preferentially lost.
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PONTECORVO, G. Induction of Directional Chromosome Elimination in Somatic Cell Hybrids. Nature 230, 367–369 (1971). https://doi.org/10.1038/230367a0
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DOI: https://doi.org/10.1038/230367a0
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