Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Three-dimensional Fourier Synthesis of Human Deoxyhaemoglobin at 3.5 Å Resolution

Nature volume 228, pages 516–519 (1970)Cite this article

An Erratum to this article was published on 14 November 1970

Abstract

Electron density maps of human deoxyhaemoglobin at a resolution of 3.5 Å reveal new conformations of the C-terminal residues of the β chain and confirm their contribution to the alkaline Bohr effect. A preliminary comparison of this structure with that of horse oxyhaemoglobin shows that the main differences occur at the chain termini and at certain side chains in the α1β2 interface.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Muirhead, H., Cox, J. M., Mazzarella, L., and Perutz, M. F., J. Mol. Biol., 28, 117 (1967).

    Article  CAS  Google Scholar 

  2. Bolton, W., Cox, J. M., and Perutz, M. F., J. Mol. Biol., 33, 283 (1968).

    Article  CAS  Google Scholar 

  3. Perutz, M. F., Muirhead, H., Mazzarella, L., Crowther, R. A., Greer, J., and Kilmartin, J. V., Nature, 222, 1240 (1969).

    Article  ADS  CAS  Google Scholar 

  4. Kilmartin, J. V., and Rossi-Barnardi, L., Nature, 222, 1243 (1969).

    Article  ADS  CAS  Google Scholar 

  5. Lehmann, H., and Carrell, R. W., Brit. Med. Bull., 25, 14 (1969).

    Article  CAS  Google Scholar 

  6. Perutz, M. F., and Lehmann, H., Nature, 219, 902 (1968).

    Article  ADS  CAS  Google Scholar 

  7. Stryer, L., Kendrew, J. C., and Watson, H. C., J. Mol. Biol., 8, 96 (1964).

    Article  CAS  Google Scholar 

  8. Cecil, R., and Snow, N. S., Biochem. J., 82, 247 (1962).

    Article  CAS  Google Scholar 

  9. Cecil, R., and Thomas, M. A. W., Nature, 206, 1317 (1965).

    Article  ADS  CAS  Google Scholar 

  10. Green, D. W., Ingram, V. M., and Perutz, M. F., Proc. Roy. Soc., A, 225, 287 (1954).

    Article  ADS  CAS  Google Scholar 

  11. Watson, H. C., Shotton, D. M., Cox, J. M., and Muirhead, H., Nature, 225, 806 (1970).

    Article  ADS  CAS  Google Scholar 

  12. North, A. C. T., Phillips, D. C., and Mathews, F. S., Acta Cryst., 24, 351 (1968).

    Article  Google Scholar 

  13. Dickerson, R. E., Kendrew, J. C., and Strandberg, B. E., Acta Cryst., 14, 1188 (1961).

    Article  CAS  Google Scholar 

  14. Lipscomb, W. N., Coppola, J. C., Hartsuck, J. A., Ludwig, M. L., Muirhead, H., Searl, J., and Steitz, T. A., J. Mol. Biol., 19, 423 (1966).

    Article  CAS  Google Scholar 

  15. Blow, D. M., and Crick, F. H. C., Acta Cryst., 12, 794 (1959).

    Article  CAS  Google Scholar 

  16. Gossling, T. H., Acta Cryst., 22, 465 (1967).

    Article  CAS  Google Scholar 

  17. Richards, F. M., J. Mol. Biol., 37, 225 (1968).

    Article  CAS  Google Scholar 

  18. Nobbs, C. L., Watson, H. C., and Kendrew, J. C., Nature, 209, 339 (1966).

    Article  ADS  CAS  Google Scholar 

  19. Perutz, M. F., Muirhead, H., Cox, J. M., Goaman, L. C. G., Mathews, F. S., McGandy, E. L., and Webb, L. E., Nature, 219, 29 (1968).

    Article  ADS  CAS  Google Scholar 

  20. Perutz, M. F., Muirhead, H., Cox, J. M., and Goaman, L. C. G., Nature, 219, 131 (1968).

    Article  ADS  CAS  Google Scholar 

  21. Perutz, M. F., J. Mol. Biol., 13, 646 (1965).

    Article  CAS  Google Scholar 

Download references

Author information

Author notes

  1. HILARY MUIRHEAD

    Present address: Molecular Enzymology Laboratory, Department of Biochemistry, University of Bristol, Bristol, BS8 1TD

  2. J. GREER

    Present address: Department of Molecular Biophysics, Yale University, New Haven, Connecticut, 06520

Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH

    HILARY MUIRHEAD & J. GREER

Authors
  1. HILARY MUIRHEAD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. GREER
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

MUIRHEAD, H., GREER, J. Three-dimensional Fourier Synthesis of Human Deoxyhaemoglobin at 3.5 Å Resolution. Nature 228, 516–519 (1970). https://doi.org/10.1038/228516a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/228516a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing