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New Molecular Model for the Long-range Elasticity of Elastin

Abstract

THE traditional type of elastomer consists of a random network of kinetically free chains linked together by means of stable cross-links: in the case of vulcanized Hevea rubber by sulphur bridges and in the case of the elastic insect protein, resilin, by di- and tri-tyrosine residues1. The elastic force is caused by the random thermal agitation of the chains whose configurational entropy decreases with strain, while the changes in internal energy remain negligible. Some problems posed by the elastic behaviour of elastin, however, have led us to consider a fundamentally different type of elastomer.

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References

  1. Andersen, S. O., Acta Physiol. Scand., 66, Suppl. 263 (1966).

    Google Scholar 

  2. Hoeve, C. A. J., and Flory, P. J., J. Amer. Chem. Soc., 80, 6523 (1958).

    Article  CAS  Google Scholar 

  3. Volpin, D., and Ciferri, A., Nature, 225, 382 (1970); and in Chemistry and Molecular Biology of the Intercellular Matrix (edit. by Balazs, E. A.), 1, 691 (Academic Press, London, 1970).

    Google Scholar 

  4. Wiegand, W. B., and Snyder, J. W., IRI Trans., 10, 234 (1934).

    CAS  Google Scholar 

  5. Weis-Fogh, T., J. Mol. Biol., 3, 520 (1961).

    Article  CAS  Google Scholar 

  6. Weis-Fogh, T., and Andersen, S. O., Proc. NATO Advanced Study Inst., Santa Margherita, 1969; Chemistry and Molecular Biology of the Intercellular Matrix (edit. by Balazs, E. A.), 1, 671 (Academic Press, London, 1970).

    Google Scholar 

  7. Partridge, S. M., in The Physiology and Biochemistry of Muscle as a Food (edit. by Briskey, E. F., Cassens, R. C., and Trautman, F. C.), 327 (Univ. Wisconsin Press, Madison, 1966).

    Google Scholar 

  8. Thomas, J., Elsden, D. F., and Partridge, S. M., Nature, 200, 651 (1963).

    Article  ADS  CAS  Google Scholar 

  9. Franzblau, C., Sinex, F. M., Faris, B., and Lampidis, R., Biochem. Biophys. Res. Commun., 21, 575 (1965).

    Article  CAS  Google Scholar 

  10. Lent, R. W., Smigh, B., Salcedo, L. L., Faris, B., and Franzblau, L., Biochemistry, 8, 2837 (1969).

    Article  CAS  Google Scholar 

  11. Partridge, S. M., Advan. Protein Chem., 17, 227 (1962).

    Article  CAS  Google Scholar 

  12. Sandberg, L. B., Hackett, T. N., and Carnes, W. H., quoted by Partridge, S. M., in Chemistry and Molecular Biology of the Intercellular Matrix (edit. by Balazs, E. A.), 1, 593 (Academic Press, London, 1970).

    Google Scholar 

  13. Partridge, S. M., Davis, H. F., and Adair, G. S., Biochem. J., 61, 11 (1955).

    Article  CAS  Google Scholar 

  14. Clarke, E. W., and Rothschild, Lord, Proc. Roy. Soc., B, 147, 316 (1957).

    Article  ADS  CAS  Google Scholar 

  15. Handbook of Chemistry and Physics (edit. by Weast, R. C.), forty-eighth ed., F.29 (Chemical Rubber Co., Cleveland, 1967).

  16. Nemethy, C., and Scheraga, H. A., J. Phys. Chem., 66, 1773 (1962).

    Article  CAS  Google Scholar 

Download references

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WEIS-FOGH, T., ANDERSEN, S. New Molecular Model for the Long-range Elasticity of Elastin. Nature 227, 718–721 (1970). https://doi.org/10.1038/227718a0

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