Abstract
THE proteolytic activity of gastric juice and of gastric mucosal extracts from most patients with proven gastric or duodenal ulceration differs from that of most normal subjects, as judged by the respective proteolytic pH-activity curves1. Agar gel electrophoresis of gastric juice is a sensitive means of detecting the individual pepsins responsible for this activity. In normal gastric juice, eight zones of proteolytic activity may be detected, but not all of the responsible enzymes are present in every subject2. One of these enzymes, pepsin 1, seems to be more prominent in some patients with peptic ulcer than in normal subjects3. I now record the frequency of occurrence of the individual gastric proteinases in patients with gastric and duodenal ulceration, and demonstrate that one of them, pepsin 1, is increased in comparison with the known frequency in normal subjects4.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Taylor, W. H., J. Clin. Path., 12, 338 (1959).
Etherington, D. J., and Taylor, W. H., Nature, 216, 279 (1967).
Taylor, W. H., Handbook of Physiology (edit. by Code, C. F., and Heide, W.), Section 6, 5, 2567 (American Physiological Society, Washington, 1968).
Etherington, D. J., and Taylor, W. H., Biochem. J., 113, 663 (1969).
Kay, A. W., Brit. Med. J., 2, 77 (1953).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
TAYLOR, W. Pepsins of Patients with Peptic Ulcer. Nature 227, 76–77 (1970). https://doi.org/10.1038/227076a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/227076a0
This article is cited by
-
Acid and the basis for cellular plasticity and reprogramming in gastric repair and cancer
Nature Reviews Gastroenterology & Hepatology (2018)
-
Pepsin concentration in gastroduodenal biopsy homogenates in chronic ulcer disease
Digestive Diseases and Sciences (1994)
-
Studies on acid protease fractions and gastric mucosal atrophy
Gastroenterologia Japonica (1980)
-
Studies on acid protease fractions and gastric mucosal atrophy
Gastroenterologia Japonica (1980)
-
Exogenous and endogenous acid and pepsins in the pathogenesis of duodenal ulcers in the rat
Digestive Diseases and Sciences (1980)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.