Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Effects of Interferon Inducers on the Intracellular Growth of the Protozoan Parasite, Leishmania donovani

Abstract

SOME inducers of interferon, as well as interferon itself, have been shown to afford some protection against trophozoite1 and sporozoite induced malaria2 and Toxoplasma gondii in L cells3. The effect is similar to the way bacterial endotoxin stimulates host resistance to bacterial infection4,5 and enhances protection against rodent malaria6,7 and trypanosomes8,9.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Schultz, W. W., Huang, K.-Y., and Gordon, F. B., Nature 220, 709 (1968).

    Article  ADS  CAS  Google Scholar 

  2. Jahiel, R., Nussenzweig, R. S., Vanderberg, J., and Vilček, J., Nature, 220, 710 (1968).

    Article  ADS  CAS  Google Scholar 

  3. Remington, J. S., and Merigan, T. C., Science, 161, 804 (1968).

    Article  ADS  CAS  Google Scholar 

  4. Rowley, D., in Bacterial Endotoxins (edit. by Landy, M., and Braun, W.) (Rutgers Univ. Press, New Brunswick, 1964).

    Google Scholar 

  5. Fukui, G. M., in Bacterial Endotoxins (edit. by Landy, M., and Braun, W.) (Rutgers Univ. Press, New Brunswick, 1964).

    Google Scholar 

  6. MacGregor, R. R., Sheagren, J. N., and Wolff, S. M., J. Immunol., 102, 131 (1969).

    CAS  PubMed  Google Scholar 

  7. Martin, L. K., Einheber, A., Sadun, E. H., and Wren, R. E., Exp. Parasitol., 20, 186 (1967).

    Article  CAS  Google Scholar 

  8. Singer, I., Kimble, III, E. T., and Ritts, jun., R. E., J. Infect. Dis., 114, 243 (1964).

    Article  CAS  Google Scholar 

  9. Styles, T. J., J. Parasitol., 51, 650 (1965).

    Article  CAS  Google Scholar 

  10. Field, A. K., Tytell, A. A., Lampson, G. P., and Hilleman, M. R., Proc. US Nat. Acad. Sci., 58, 1004 (1967).

    Article  ADS  CAS  Google Scholar 

  11. Baron, S., and Buckler, C. E., Science, 141, 1061 (1963).

    Article  ADS  CAS  Google Scholar 

  12. Stinebring, W. R., and Youngner, J. S., Nature, 204, 712 (1964).

    Article  ADS  CAS  Google Scholar 

  13. Ho, M., Science, 146, 1472 (1964).

    Article  ADS  CAS  Google Scholar 

  14. Stauber, L. A., Exp. Parasitol., 18, 1 (1966).

    Article  CAS  Google Scholar 

  15. Stauber, L. A., Rice Inst. Pamph., 45, 80 (1958).

    Google Scholar 

  16. Martínez-Silva, R., Correa, A., Colon, J., and Chiriboga, J., Abst. Nineteenth Ann. Meeting of Tissue Culture Assoc. (San Juan, Puerto Rico, 1968).

  17. Braun, W., and Nakano, M., Proc. Soc. Exp. Biol. Med., 119, 701 (1965).

    Article  CAS  Google Scholar 

  18. Braun, W., Nakano, M., and Freedman, H., Fed. Proc., 25, 370 (1966).

    Google Scholar 

  19. Braun, W., and Kessel, R. W. I., in Bacterial Endotoxins (edit. by Landy, M., and Braun, W.) (Rutgers Univ. Press, New Brunswick, 1964).

    Google Scholar 

  20. Braun, W., and Nakano, M., Science, 157, 819 (1967).

    Article  ADS  CAS  Google Scholar 

  21. Ho, M., Postic, B., and Ke, Y. H., in Ciba Foundation Symposium on Interferon (edit. by Wolstenholme, G. E. W., and O'Connor, M.) (Churchill, London, 1968).

    Google Scholar 

  22. Kono, Y., and Ho, M., Virology, 25, 162 (1965).

    Article  Google Scholar 

  23. Cremer, N., and Watson, D. W., Proc. Soc. Exp. Biol. Med., 95, 510 (1957).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

HERMAN, R., BARON, S. Effects of Interferon Inducers on the Intracellular Growth of the Protozoan Parasite, Leishmania donovani. Nature 226, 168–170 (1970). https://doi.org/10.1038/226168a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/226168a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing