Abstract
RECENT discoveries1–7 seem to indicate that humoral immune responses to some antigens require the interaction of thymus-dependent and thymus-independent cells. An antigen sensitive cell of thymic origin would exist, which is responsible for recognizing antigen, and which differs from the antigen insensitive cells from bone marrow capable of synthesizing antibody. Support for this view comes from experiments involving transplantation of thymus or thoracic duct lymphoid cells into animals which were rendered incapable of forming antibody to sheep cells (SRBC) by irradiation or neonatal thymectomy. An interaction between thymus cells and precursors of antibody forming cells was first demonstrated by injecting irradiated mice with SRBC mixed with thymus cells, marrow cells, or both1. The antibody response in mice given both cell types exceeded the sum of responses to the individual cell types. Thymus or thoracic duct lymphocytes mixed with SRBC and injected into neonatally thymectomized mice elicited antibody responses comparable with those in normal mice2–5. From these experiments and others in which adult mice were thymectomized and irradiated but protected from death by the presence of bone marrow, and injected with SRBC mixed with thoracic duct lymphocytes, it seems clear that antibody synthesizing cells were derived from thymus-independent cells by way of precursors in the marrow. Thus responses to SRBC, like those to other antigens, rely on a thymus-independent population for antibody production. We conclude that the lymphoid system is organized into thymus-dependent and thymus-independent lymphoid populations and that the latter are involved in synthesizing and secreting antibody.
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References
Claman, H. N., Chaperon, E. A., and Triplett, R. F., Proc. Soc. Exp. Biol. Med., 122, 1167 (1966).
Miller, J. F. A. P., and Mitchell, G. F., Nature, 216, 659 (1967).
Miller, J. F. A. P., and Mitchell, G. F., J. Exp. Med., 128, 801 (1969).
Miller, J. F. A. P., and Mitchell, G. F., J. Exp. Med., 128, 821 (1969).
Mitchell, G. F., and Miller, J. F. A. P., Proc. US Nat. Acad. Sci., 59, 296 (1968).
Nossal, G. J. V., Cunningham, A., Mitchell, G. F., and Miller, J. F. A. P., J. Exp. Med., 128, 839 (1969).
Martin, W. J., and Miller, J. F. A. P., J. Exp. Med., 128, 855 (1969).
Warner, N. L., and Szenberg, A., in The Thymus in Immunology (edit. by Good, R. A., and Gabrielsen, A. E.), 395 (Hoeber-Harper, New York, 1964).
Cooper, M. D., Peterson, R. D. A., South, M. A., and Good, R. A., J. Exp. Med., 123, 75 (1966).
Good, R. A., Cooper, M. D., Peterson, R. D. A., Kellum, M. S., Sutherland, D. E. R., and Gabrielsen, A. E., Ann. NY Acad. Sci., 135, 451 (1966).
Basch, R. S., Inter. Arch. Allergy, 30, 105 (1966).
Fahey, J. L., Berth, W. F., and Law, L. W., J. Nat. Cancer Inst., 35, 663 (1965).
Hess, M. W., and Stoner, R. D., Intern. Arch. Allergy, 30, 37 (1966).
Miller, J. F. A. P., Ting, R. C., and Law, L. W., Proc. Soc. Exp. Biol., Med., 116, 323 (1964).
Humphrey, J. H., Parrott, D. M. V., and East, J., Immunology, 7, 419 (1964).
Miller, J. F. A. P., De Burgh, P. M., and Grant, G. A., Nature, 208, 1332 (1965).
Good, R. A., and Finstad, J., J. Nat. Cancer Inst. Monog., 31, 41 (1969).
Finstad, J., Fange, R., and Good, R. A., in Advances in Experimental Medicine and Biology (Plenum, New York; in the press).
Ford, W. L., Gowans, J. L., and McCullagh, P. J., in The Thymus: Experimental and Clinical Study (edit. by Wolstenholme, G. E. W., and Porter, R.), 58 (Churchill, London, 1966).
Tyan, M. L., and Cole, L. J., Nature, 208, 1223 (1965).
Tyan, M. L., Transplantation, 4, 557 (1966).
Davies, A. J. S., Leuchars, E., Wallis, V., Marchant, R., and Elliott, E. V., Transplantation, 5, 222 (1967).
Stutman, O., Yunis, E. J., and Good, R. A., Proc. Transplant. Soc., 1, 641 (1969).
Di George, A. M., J. Ped., 67, 907 (1965).
Cleveland, W. W., Fogel, B. J., Brown, W. T., and Day, H. E. M., Lancet. ii, 1211 (1968).
Cleveland, W., Fogel, B. J., and Kay, H. E., J. Clin. Invest., 47, 20a (1968).
Huber, J., Cholnoky, P., and Zoethout, H. E., Arch. Dis. Child., 42, 190 (1967).
Bruton, D. C., Pediatrics, 9, 722 (1952).
Dalmasso, A. P., Martinez, C., Sjodin, K., and Good, R. A., J. Exp. Med., 118, 1089 (1963).
Sinclair, U. R. S., and Elliott, E. V., Immunology, 15, 325 (1968).
Ovary, Z., and Benacerraf, B., Proc. Soc. Exp. Biol. Med., 114, 72 (1963).
Borek, F., and Silverstein, A. M., Nature, 205, 299 (1965).
Paul, W. E., Siskind, G. W., and Benacerraf, B., J. Exp. Med., 123, 689 (1966).
Paul, W. E., Siskind, G. W., Benacerraf, B., and Ovary, Z., J. Immunol., 99, 760 (1967).
Uhr, J. W., Salvin, S. B., and Papenheimer, A. M., J. Exp. Med., 105, 11 (1957).
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GOOD, R., CAIN, W. Relationship between Thymus-dependent Cells and Humoral Immunity. Nature 226, 1256–1257 (1970). https://doi.org/10.1038/2261256a0
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DOI: https://doi.org/10.1038/2261256a0
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