Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

In vitro Synthesis of Hb Hammersmith (CD1 Phe→Ser)

Nature volume 225, pages 860–861 (1970)Cite this article

Abstract

RED cells of patients heterozygous for Hb A and the unstable haemoglobin, Hb Köln (FG5 Val→Met)1 contain only 10–15 per cent of the abnormal haemoglobin. This was found to arise from defective synthesis of the abnormal β Köln chain2–4, and not from its removal from cells by Heinz body formation. The techniques used in these studies might, however, have caused denaturation of Hb Köln and produced falsely low values for the proportion of Hb Köln synthesized. The relative rates of synthesis of Hb A and Hb Hammersmith (CD1 Phe→Ser)5, another unstable haemoglobin, have now been studied, using identical techniques, to test the validity of the Hb Köln experiments and to compare the synthesis of Hb Hammersmith with that of Hb Köln.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Carrell, R. W., Lehmann, H., and Hutchinson, H. E., Nature, 210, 915 (1966).

    Article  ADS  CAS  Google Scholar 

  2. White, J. M., and Brain, M. C., Abst. Thirteen Cong. Int. Soc. Haematol., 65 (Abstr.) (1968).

  3. Brain, M. C., and White, J. M., J. Physiol., 202, 26P (1969).

    CAS  PubMed  Google Scholar 

  4. White, J. M., and Brain, M. C., Brit. J. Haemat., 18, 195 (1970).

    Article  CAS  Google Scholar 

  5. Dacie, J. V., Shinton, N. K., Gaffney, P. J., Carrell, R. W., and Lehmann, H., Nature, 216, 663 (1967).

    Article  ADS  CAS  Google Scholar 

  6. Lingrel, J. B., and Borsook, H., Biochemistry, 2, 309 (1963).

    Article  CAS  Google Scholar 

  7. Clegg, J. B., Naughton, M. A., and Weatherall, D. J., J. Molec. Biol., 19, 91 (1966).

    Article  CAS  Google Scholar 

  8. Jacob, H. S., Brain, M. C., Dacie, J. V., Carrell, R. W., and Lehmann, H., Nature, 218, 1214 (1968).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. MRC Group for Haemolytic Mechanisms, Royal Postgraduate Medical School, Hammersmith Hospital, London, W12

    J. M. WHITE & J. V. DACIE

Authors
  1. J. M. WHITE
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. V. DACIE
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

WHITE, J., DACIE, J. In vitro Synthesis of Hb Hammersmith (CD1 Phe→Ser). Nature 225, 860–861 (1970). https://doi.org/10.1038/225860a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/225860a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing