Abstract
WE wish to report a new method with which we have been able to measure the sodium and potassium conductance changes postulated by Hodgkin and Huxley1 in the course of a single action potential. To measure the membrane conductance at any desired time during the course of the action potential, we have designed a membrane potential control system which can be turned on and off quickly with an electronic switch.
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References
Hodgkin, A. L., and Huxley, A. F., J. Physiol., 117, 500 (1952).
Rojas, E., and Canessa-Fischer, M., J. Gen. Physiol., 52, 240 (1968).
Atwater, I., Bezanilla, F., and Rojas, E., J. Physiol., 201, 657 (1969).
Cole, K. S., and Curtis, H. J., J. Gen. Physiol., 22 649 (1939).
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ROJAS, E., BEZANILLA, F. & TAYLOR, R. Demonstration of Sodium and Potassium Conductance Changes during a Nerve Action Potential. Nature 225, 747–748 (1970). https://doi.org/10.1038/225747a0
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DOI: https://doi.org/10.1038/225747a0
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