Abstract
CALCIUM ions are necessary for the maintenance of the normal, low permeability of cell plasma membranes1–3: if animal cells are incubated in media free of Ca2+ the passive permeability of the membranes increases, and the cells are unable to maintain their normal concentration gradients of K+ and Na+ (refs. 4, 5). Recent work has suggested, however, that a raised level of intracellular Ca2+ specifically increases the passive permeability of erythrocyte membranes to K+. Liver cells possess an energy dependent mechanism which can bring about the net extrusion of Ca2+ that has accumulated during incubation at 1° C (refs. 7, 8). It was therefore of interest to examine the relationship between the lowering of intracellular Ca2+ thus produced and the accompanying recovery of the K+ and Na+ composition of the cells.
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VAN ROSSUM, G. Relation of Intracellular Ca2+ to Retention of K+ by Liver Slices. Nature 225, 638–639 (1970). https://doi.org/10.1038/225638a0
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DOI: https://doi.org/10.1038/225638a0
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