Correlation of Bradykinin Structure with ability to increase Vascular Permeability

Abstract

OF the chemical substances that possibly mediate the inflammatory response^1,2, bradykinin (H–L-Arg–L-Pro–L-Pro–Gly–L-Phe–L-Ser–L-Pro–L-Phe–L-Arg–OH) warrants special study because four of its pharmacological activities—the capacity to increase vascular permeability and to initiate vasodilation, pain and the emigration of leucocytes—are all encountered in acute inflammation³. We have sought a correlation of the structure of bradykinin with its ability to increase vascular permeability. The effect on activity was investigated when each of the nine amino-acids in the peptide chain was replaced in turn with L-alanine.