Abstract
γ-Aminobutyric acid is shown to be specifically released from the brain during synaptic inhibition, which suggests that it may be an important central inhibitory transmitter.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Roberts, E., and Frankel, S., Fed. Proc., 9, 219 (1950).
Otsuka, M., Iversen, L. L., Hall, Z. W., and Kravitz, E. A., Proc. US Nat. Acad. Sci., 56, 1110 (1966).
Iwama, K., and Jasper, H. H., J. Physiol., 138, 365 (1957).
Krnjević, K., Randić, M., and Straughan, D. W., J. Physiol., 184, 16 (1966).
Krnjević, K., and Schwartz, S., Exp. Brain Res., 3, 320 (1967).
Obata, K., and Takeda, K., J. Neurochem., 16, 1043 (1969).
Florey, E., and MacLennan, H., J. Physiol., 129, 384 (1955).
Jasper, H. H., Khan, R. T., and Elliott, K. A. C., Science, 147, 1448 (1965).
Crowshaw, K., Jessup, S. J., and Ramwell, P. W., Biochem. J., 103, 79 (1967).
Srinivasan, V., Neal, M. J., and Mitchell, J. F., J. Neurochem., 16, 1235 (1969).
Neal, M. J., and Iversen, L. L., J. Neurochem., 16, 1245 (1969).
Mitchell, J. F., J. Physiol., 165, 98 (1963).
Moore, S., and Stein, W. H., J. Biol. Chem., 176, 367 (1948).
Iversen, L. L., and Kravitz, E. A., J. Neurochem., 15, 609 (1968).
Mitchell, J. F., and Srinivasan, V., J. Physiol., 204, 23P (1969).
Burgen, A. S. V., and Spero, L., Brit. J. Pharmacol. Chemother., 34, 99 (1968).
Li, Ch.-L., Oritz-Golvin, A., Chou, S. N., and Howard, S. Y., J. Neurophysiol., 23, 592 (1960).
Krnjević, K., and Phillis, J. W., J. Physiol., 165, 274 (1963).
Iversen, L. L., and Neal, M. J., J. Neurochem., 15, 1141 (1968).
Lovell, R. A., and Elliott, K. A. C., J. Neurochem., 10, 479 (1963).
Tower, D. B., in Inhibition in the Nervous System and γ-Aminobutyric Acid (edit. by Roberts, E.) (Pergamon, London, 1960).
Roberts, E., in Structure and Function of Inhibitory Neuronal Mechanisms (edit. by von Euler, C., Skoglund, S., and Soderberg, U.) (Pergamon, London, 1968).
Hayashi, T., in Inhibition in the Nervous System and γ-Aminobutyric Acid (edit. by Roberts, E.) (Pergamon, London, 1960).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MITCHELL, J., SRINIVASAN, V. Release of 3H-γ-Aminobutyric Acid from the Brain during Synaptic Inhibition. Nature 224, 663–666 (1969). https://doi.org/10.1038/224663a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/224663a0
This article is cited by
-
The emergence of the cortical GABAergic neuron: with particular reference to some peptidergic subpopulations
Journal of Neurocytology (1993)
-
Light-evoked release of glycine from the retina
Nature (1974)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.