Abstract
MORFAMQUAT dichloride (MFQ) is a herbicide (Plant Protection Limited) which produces degeneration and necrosis of the proximal convoluted tubules in the kidney when administered to rats and dogs in acutely toxic doses. Ninety day feeding tests have, however, shown that low dietary concentrations (0.015 per cent) cause marked enlargement of certain cells in a circumscribed area of the kidney, remote from the proximal tubules and this preliminary report describes the histology, histo-chemistry and electron microscopy of these abnormal cells in rat kidneys.
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References
Scarpelli, D. G., and Pearse, A. G. E., J. Histochem. Cytochem., 6, 369 (1958).
Nachlas, M. M., Crawford, D. T., and Seligman, A. M., J. Histochem. Cytochem., 5, 264 (1957).
Holt, S. J., and Withers, R. F. J., Nature, 170, 1012 (1952).
Glenner, G. G., Burtner, H. J., and Brown, G. W., J. Histochem. Cytochem, 5, 591 (1957).
Scarpelli, D. G., Hess, R., and Pearse, A. G. E., J. Biophys. Biochem. Cytol., 4, 747 (1958).
Burstone, M. S., J. Histochem. Cytochem., 7, 112 (1959).
Nachlas, M. M., Tsou, K-C., de Souza, E., Cheng, C-S., and Seligman, A. M., J. Histochem. Cytochem., 5, 420 (1957).
Pearse, A. G. E., in Histochemistry, Theoretical and Applied, 911 (J. and A.Churchill, London, 1961).
Silver, B. B., in Abstracts from Europ. Symp. on Cytochemistry in Electron Microscopy, 33 (Royal Microscopical Society, 1968).
Rhodin, J., Int. Rev. Cytol., 7, 485 (1958).
Novikoff, A. B., in Biology of Pyelonephritis (Henry Ford Hospital International Symposium), 113 (Little and Brown, Boston, 1960).
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FERGUSON, D., ETHERTON, J. & HAYES, M. Mitochondrial Increase after Long-term Feeding of Morfamquat. Nature 224, 83–84 (1969). https://doi.org/10.1038/224083b0
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DOI: https://doi.org/10.1038/224083b0
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