Abstract
Transient and catabolite repression of the synthesis of β-galactosidase in E. coli are related phenomena, the result of a decreased intracellular concentration of cyclic AMP. The lac operon promoter is the site of action of the cyclic AMP.
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References
Perlman, R., and Pastan, I., Biochem. Biophys. Res. Commun., 30, 656 (1968).
Perlman, R. L., and Pastan, I., J. Biol. Chem., 243, 5420 (1968).
Pastan, I., and Perlman, R. L., Proc. US Nat. Acad. Sci., 61, 1336 (1968).
Goldenbaum, P. E., and Dobrogosz, W. J., Biochem. Biophys. Res. Commun., 33, 828 (1968).
Ullmann, A., and Monod, J., FEBS Letters, 2, 57 (1968).
Magasanik, B., Cold Spring Harbor Symp. Quant. Biol., 26, 193 (1961).
Boezi, J. A., and Cowie, D. B., Biophys. J., 1, 639 (1961).
Tyler, B., Loomis, jun., W. F., and Magasanik, B., J. Bacteriol., 94, 2001 (1967).
Cohn, M., and Horibata, K., J. Bacteriol., 78, 601 (1959).
Makman, R. S., and Sutherland, E. W., J. Biol. Chem., 240, 1309 (1965).
Hsie, A. W., and Rickenberg, H. W., Biochem. Biophys. Res. Commun., 29, 303 (1967).
Silverstone, A. E., Magasanik, B., Reznikoff, W. S., Miller, J. H., and Beckwith, J. R., Nature, 221, 1012 (1969).
Miller, J. H., Ippen, K., Scaife, J. G., and Beckwith, J. R., J. Mol. Biol., 38, 413 (1968).
Loomis, jun., W. F., and Magasanik, B., Biochem. Biophys. Res. Commun., 20, 230 (1965).
Rickenberg, H. V., Hsie, A. W., and Janacek, J., Biochem. Biophys. Res. Commun., 31, 603 (1968).
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PERLMAN, R., DE CROMBRUGGHE, B. & PASTAN, I. Cyclic AMP regulates Catabolite and Transient Repression in E. coli. Nature 223, 810–812 (1969). https://doi.org/10.1038/223810a0
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DOI: https://doi.org/10.1038/223810a0
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