Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Secretion of α-Lactalbumin into Milk and its Relevance to the Organization and Control of Lactose Synthetase

Abstract

α-LACTALBUMIN has recently been recognized as a component of lactose synthetase1; it has long been known as a major protein component of milk whey2. Studies of the biosynthesis and secretion of α-lactalbumin in preparations from the lactating guinea-pig mammary gland3 indicate that the protein found in milk arises not by leakage and breakdown of mammary cells but is specifically secreted. The relatively high concentration of α-lactalbumin in milks, l mg/ml. in bovine milk4 and more than 5 mg/ml. in guinea-pig milk5, supports this view.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Brodbeck, U., Denton, W. L., Tanahashi, N., and Ebner, K. E., J. Biol. Chem., 242, 1391 (1967).

    CAS  PubMed  Google Scholar 

  2. Sorensen, M., and Sorensen, S. P. L., CR Trav. Lab. Carlsberg, Ser. Chim., 25, 55 (1939).

    Google Scholar 

  3. Brew, K., and Campbell, P. N., Biochem. J., 102, 265 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Bell, K., and McKenzie, H. A., Nature, 204, 1275 (1964).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Brew, K., and Campbell, P. N., Biochem. J., 102, 258 (1967).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Brodbeck, U., and Ebner, K. E., J. Biol. Chem., 241, 762 (1966).

    CAS  PubMed  Google Scholar 

  7. Brew, K., Vanaman, T. C., and Hill, R. L., Proc. US Nat. Acad. Sci., 59, 491 (1968).

    Article  ADS  CAS  Google Scholar 

  8. McGuire, E. J., Jourdain, G. W., Carlson, D. M., and Roseman, S., J. Biol. Chem., 240, PC 4113 (1965).

  9. Turkington, R. W., Brew, K., Vanaman, T. C., and Hill, R. L., J. Biol. Chem., 243, 3382 (1968).

    CAS  PubMed  Google Scholar 

  10. Brodbeck, U., and Ebner, K. E., J. Biol. Chem., 241, 5526 (1966).

    CAS  PubMed  Google Scholar 

  11. Coffey, R. G., and Reithel, J., Biochem. J., 109, 169 (1968).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Lawford, G. R., and Schachter, H., J. Biol. Chem., 241, 5408 (1966).

    CAS  PubMed  Google Scholar 

  13. Siekevitz, P., and Palade, G. E., J. Biophys. Biochem. Cytol., 7, 619 (1960).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Caro, L. G., and Palade, G. E., J. Coll. Biol., 20, 473 (1964).

    Article  CAS  Google Scholar 

  15. Peters, jun., T., J. Biol. Chem., 237, 1186 (1962).

    CAS  PubMed  Google Scholar 

  16. Helminen, H. J., and Ericsson, J. L. E., J. Ultrastruct. Res., 25, 193 (1968).

    Article  CAS  PubMed  Google Scholar 

  17. Brew, K., Vanaman, T. C., and Hill, R. L., J. Biol. Chem., 242, 3747 (1967).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

BREW, K. Secretion of α-Lactalbumin into Milk and its Relevance to the Organization and Control of Lactose Synthetase. Nature 222, 671–672 (1969). https://doi.org/10.1038/222671a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/222671a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing