Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Do Genes determine Sex?

Abstract

Chromosomes may control the duration of the cell cycle and the mitotic rate. Sex differentiation may be initiated by differential growth, and the human Y chromosome may increase the number of mitoses.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Jost, A., in Organogenesis (edit. by de Haan, R. L., and Ursprung, H.), 611 (Holt, Rinehart and Winston, New York, 1965); Gallien, L. G., ibid., 583.

    Google Scholar 

  2. Arey, L. B., Developmental Anatomy, seventh ed. (Saunders, Philadelphia and London, 1966). Gillman, J., Contr. Embryol, 32, 81 (1948). van Wagenen, G., and Simpson, M. E., Embryology of the Ovary and Testis Homo sapiens and Macaca mulatta (Yale University Press, New Haven and London, 1965).

    Google Scholar 

  3. Singh, R. P., and Carr, D. H., Anat. Rec., 155, 369 (1966).

    Article  CAS  Google Scholar 

  4. Correns, C., Die Bestimmung und Vererbung des Geschlechtes, nach neuen Versuchen mit höheren Pflanzen (Borntraeger, Berlin, 1907).

    Google Scholar 

  5. Correns, C., Die Vererbung und Bestimmung des Geschlechtes (Borntraeger, Berlin, 1913). Correns, C., Bestimmung, Vererbung und Verteilung des Geschlechtes bei den höheren Pflanzen (Borntraeger, Berlin, 1928).

    Google Scholar 

  6. von Wettstein, F., Naturwissenschaften, 12, 761 (1924).

    Article  ADS  Google Scholar 

  7. Hartmann, M., Die Sexualität (G. Fischer Verlag, Stuttgart, 1956).

    Google Scholar 

  8. Muller, H. J., Amer. Nat., 66, 118 (1932).

    Article  Google Scholar 

  9. Goldschmidt, R. B., Bibl. Genet., 11, 1 (1934). Bridges, C. B., Amer. Nat., 59, 127 (1925).

    Google Scholar 

  10. Stern, C., Z. Indukt. Abstamm. Vererb'lehre, 44, 187 (1927).

    Google Scholar 

  11. Bridges, C. B., in Sex and Internal Secretions (edit. by Allen, E.), second ed., 15 (Baillière, Tindall and Cox, London, 1939).

    Google Scholar 

  12. Dobzhansky, T., and Schultz, J., J. Genet., 28, 349 (1934).

    Article  Google Scholar 

  13. Goldschmidt, R. B., Wilhelm Roux Arch. Entw'mech. Org., 24, 1 (1920).

    Google Scholar 

  14. Stern, C., Human Genetics (W. H. Freeman and Co., San Francisco and London, 1961). Ford, C. E., in Intersexuality (edit. by Overzier, C.), 23 (Academic Press, New York and London, 1963).

    Google Scholar 

  15. Stern, C., Amer. J. Med., 34, 715 (1963).

    Article  CAS  Google Scholar 

  16. Ohno, S., Sex Chromosomes and Sex-linked Genes (Springer Verlag, Berlin, Heidelberg and New York, 1967).

    Book  Google Scholar 

  17. Hamerton, J. L., Nature, 219, 910 (1968).

    Article  ADS  CAS  Google Scholar 

  18. Muller, H. J., and Painter, T. S., Z. Indukt. Abstamm. VererbLehre, 62, 316 (1932). Heitz, E., Z. Zellforsch. Mikrosk. Anat., 20, 237 (1933).

    Google Scholar 

  19. Mather, K., Proc. Roy. Soc., B, 132, 308 (1944).

    ADS  Google Scholar 

  20. Lyon, M. F., in The Sex Chromatin (edit. by Moore, K. L.), 370 (Saunders, Philadelphia and London, 1966).

    Google Scholar 

  21. Penrose, L. S., Brit. Med. J., 1, 321 (1968). Holt, S. B., The Genetics of Dermal Ridges (Thomas, Springfield, Illinois, 1968).

    Google Scholar 

  22. Müntzing, A., Hereditas, 57, 432 (1967).

    Article  Google Scholar 

  23. Ayonoadu, U. W., and Rees, H., Exp. Cell Res., 52, 284 (1968).

    Article  CAS  Google Scholar 

  24. Lennartz, K. J., Schümmelfeder, N., and Maurer, W., Naturwissenschaften, 53, 21 (1966).

    Article  ADS  CAS  Google Scholar 

  25. Van't Hof, J., Exp. Cell Res., 39, 48 (1965).

    Article  CAS  Google Scholar 

  26. Darlington, C. D., and Thomas, P. T., Proc. Roy. Soc., B, 130, 127 (1941).

    ADS  Google Scholar 

  27. White, M. J. D., J. Genet., 40, 67 (1940).

    Article  Google Scholar 

  28. Ricci, U., Dallapiccola, B., Ventimiglia, B., Tiepolo, L., and Fraccaro, M., Cytogenetics, 7, 249 (1968).

    Article  CAS  Google Scholar 

  29. Ayonoadu, U., and Rees, H., Genetica, 39, 75 (1968). Cameron, M. F., and Rees, H., Heredity, 22, 446 (1967).

    Article  Google Scholar 

  30. Painter, T. S., J. Exp. Zool., 50, 441 (1928); Gregory, P. W., and Castle, W. E., ibid., 199 (1931).

    Article  Google Scholar 

  31. Chicago Conference, Standardization in Human Cytogenetics (The National Foundation, New York, 1966).

  32. Tanner, J. M., Growth at Adolescence (Blackwell, Oxford, 1962).

    Google Scholar 

  33. Court Brown, W. M., Price, W. H., and Jacobs, P. A., Brit. Med. J., 1, 325 (1968).

    Article  Google Scholar 

  34. Federman, D. D., Abnormal Sexual Development (Saunders, Philadlephia and London, 1967).

    Google Scholar 

  35. Grüneberg, H., J. Genet., 51, 95 (1952). Wright, S., Genetics, 19, 506, 537 (1934).

    Article  Google Scholar 

  36. Mittwoch, U., Sex Chromosomes (Academic Press, New York and London, 1967); Nature, 214, 554 (1967).

    Google Scholar 

  37. Goldschmidt, R. B., Theoretical Genetics (University of California Press, Berkeley, 1955). Darlington, C. D., The Evolution of Genetic Systems (Oliver and Boyd, Edinburgh and London, 1958). Swanson, C. P., Merz, T., and Young, W. J., Cytogenetics (Prentice-Hall Inc., New Jersey, 1967).

    Book  Google Scholar 

  38. Bennett, M. D., and Rees, H., Nature, 215, 93 (1967).

    Article  ADS  CAS  Google Scholar 

  39. Mittwoch, U., in Mongolism (edit. by Wolstenholme, G. E. W., anda Porter, R.), 51 (Churchill, London, 1967). Mittwoch, U., Nature, 219, 1074 (1968).

    Google Scholar 

  40. Huxley, J. S., Problems of Relative Growth (Methuen, London, 1932). Essays on Growth and Form Presented to D'Arcy Wentworth Thompson (edit. by Le Gros Clark, W. E., and Medawar P. B.) (Clarendon Press, Oxford, 1945).

    Google Scholar 

  41. Wilson, E. B., The Cell in Development and Heredity, third ed. (Macmillan, New York, 1925).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

MITTWOCH, U. Do Genes determine Sex?. Nature 221, 446–448 (1969). https://doi.org/10.1038/221446a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/221446a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing