Abstract
DIPYRIDAMOLE (Persantine–Boehringer Ingelheim, Ltd), the coronary vasodilator, inhibits the entry of adenosine into red cells, and hence its breakdown1,2—suggesting that this accounts for the pharmacological effect, for adenosine itself is a vasodilator3. The knowledge that adenosine is a potent inhibitor of platelet aggregation induced by adenosine diphosphate (ADP)4 and of experimental thrombus formation5,6 led Emmons et al.7,8 to confirm that dipyridamole has similar effects.
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References
Koss, F. W., Beisenherz, G., and Markish, R., Arzneim. Forsch., 12, 1130 (1962).
Bunag, R. A., Douglas, C. R., Imai, S., and Borne, R. M., Circ. Res., 15, 83 (1964).
Clarke, D. A., Davoll, J., Phillips, F. S., and Brown, G. B., J. Pharmacol., 106, 291 (1952).
Born, G. V. R., Proc. Int. Symp. Pathogenesis and Treatment of Thromboembolic Dis., Basle, 159 (1966).
Born, G. V. R., Honour, A. J., and Mitchell, J. R. A., Nature, 202, 761 (1964).
Born, G. V. R., and Philp, R. B., Brit. J. Exp. Pathol., 46, 57 (1965).
Emmons, P. R., Harrison, M. J. G., Honour, A. J., and Mitchell, J. R. A., Nature, 208, 255 (1965).
Emmons, P. R., Harrison, M. J. G., Honour, A. J., and Mitchell, J. R. A., Lancet, ii, 603 (1965).
Philp, R. B., and Lemieux, J. P. V., Nature, 218, 1072 (1968).
Born, G. V. R., Nature, 194, 927 (1962).
Mustard, J. F., Hegardt, B., Rowsell, H. C., and MacMillan, R. L., J. Lab. Clin. Med., 64, 548 (1964).
Bergmeyer, H. U., Methods of Enzymatic Analysis, 491 (Academic Press, NY, 1963).
Markwardt, F., Barthel, W., Glasa, E., and Hoffmann, A., Arch. Pharmak. Pathol., 257, 420 (1967).
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PHILP, R., LEMIEUX, J. Interactions of Dipyridamole and Adenosine on Platelet Aggregation. Nature 221, 1162–1164 (1969). https://doi.org/10.1038/2211162a0
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DOI: https://doi.org/10.1038/2211162a0
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