Abstract
A mutant line of the P388F lymphoma has been used as recipient for labelled DNA. A distinct peak of DNA resulted which was well separated from those given by donor and recipient DNA. This suggests true integration of DNA into the recipient genome.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Avery, O. T., MacLeod, C. M., and McCarty, M., J. Exp. Med., 79, 137 (1944).
Kraus, L. M., Nature, 192, 1055 (1961).
Szybalska, E. H., and Szybalski, W., Proc. US Nat. Acad. Sci., 48, 2926 (1962).
Ledoux, L., Prog. Nucleic Acid Res. and Mol. Biol., 4, 231 (1965).
Sirotnak, F. M., and Hutchinson, D. J., Biochim. Biophys. Acta, 36, 246 (1959).
Ricke, W. O., J. Cell. Biol., 13, 205 (1962).
Grosse, Ch., LePecq, J. B., De France, P., and Paoletti, C., Cancer Res., 25, 877 (1965).
Bendich, A., Wilczok, T., and Borenfreund, E., Science, 148, 374 (1965).
Ledoux, L., Gerber, G. R., Charles, P., Remy, J., and Remy-Defraigue, J., Experientia, 23, 16 (1967).
Ledoux, L., and Huart, R., Biochim. Biophys. Acta, 134, 209 (1967).
Ledoux, L., Charles, P., and Srögel, M., Nature, 214, 1241 (1967).
Robins, A. B., and Taylor, D. M., Nature, 214, 1228 (1968).
Ayad, S. R., and Barker, G. R., Biochem. J. (in the press).
Bodmer, W. F., and Ganesan, A. T., Genetics, 50, 717 (1964).
Levine, J. S., and Strauss, M., J. Bact., 89, 281, 288 (1965).
Fox, M. S., J. Gen. Physiol., 49, 183 (1966).
Kit, S., Dubbs, D. R., Piekarski, L. J., and Hsu, T. C., Exp. Cell Res., 31, 297 (1963).
Fox, M., and Gilbert, C. W., Intern. Radiat. Biol., 11, 339 (1966).
Fox, M., and Fox, B. W., Cancer Res., 27, 1805 (1967).
Nias, A. H. W., and Fox, M., Brit. J. Radiol., 41, 468 (1968).
Pasternak, C. A., Fischer, G. A., and Handschumacher, R. E., Cancer Res., 21, 110 (1961).
Fischer, G. A., and Sartorelli, A. S., Meth. Med. Res., 10, 247 (1964).
Sueoka, N., and Cheng, T., J. Mol. Biol., 4, 161 (1961).
Cleaver, J. E., Nature, 218, 652 (1968).
Kay, E. R. M., Trans. NY Acad. Sci., 28, 726 (1966).
Painter, R. B., and Cleaver, J. E., Nature, 216, 369 (1967).
Hakala, M. T., J. Biol. Chem., 234, 3072 (1963).
Kajiwara, K., and Mueller, G. C., Biochim. Biophys. Acta, 91, 486 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
AYAD, S., FOX, M. DNA Uptake by a Mutant Strain of Lymphoma Cells. Nature 220, 35–38 (1968). https://doi.org/10.1038/220035a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/220035a0
This article is cited by
-
Nucleic acids in circulation: Are they harmful to the host?
Journal of Biosciences (2012)
-
Spontaneous transgenesis of human B lymphocytes
Gene Therapy (2004)
-
Hypoxanthine-guanine phosphoribosyl transferase deficiency
Human Genetics (1976)
-
Alteration of melanocytes by DNA in White Plymouth Rock chickens
Nature (1974)
-
Recombinational Events between Exogenous Mouse DNA and Newly Synthesized DNA Strands of Chicken Cells in Culture
Nature New Biology (1971)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.