Abstract
CELLULAR membranes, especially those of lysosomes, become unstable in a variety of conditions—reviewed by Thomas—for example, the Arthus and Schwartzman reactions; exposure to streptolysin, ultraviolet light and carbon tetrachloride; and the muscular dystrophy of tocopherol deficiency1. Cortisone is inhibitory in most of these conditions, and has been shown to have antioxidant properties2, so we thought that other antioxidants might be effective anti-inflammatory agents. Lysosomal membranes, as well as other membranes, are composed largely of lipids and we also thought that their lysis could result from damage to such structural lipids. This idea is supported by work of Austin and Brocklehurst3, showing that the release of histamine and slow reacting substances (SRS-A) from sensitized guinea-pig lung is inhibited by long chain fatty acids. Accordingly d-α-tocopherol (vitamin E) and linoleic acid were tested as anti-inflammatory agents and found to be effective.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Thomas, L., in The Inflammatory Process (edit. by Zweifach, B. W., Grant, L., and McCluskey, R. T.) (Academic Press, New York and London, 1965).
Weissmann, G., and Thomas, L., Rec. Prog. Hormone Res., 20, 215 (1964).
Austin, K. F., and Brocklehurst, W. E., J. Exp. Med., 113, 541 (1961).
Tappel, A. L., Fed. Proc., 24, 73 (1965).
Jameson, E., Martinez, B. D., and Ryan, R. M., J. Nutrit., 80, 370 (1963).
Pearson, C. M., and Wood, F. D., Arth. Rheum., 2, 440 (1959).
Tappel, A. L., Vitamins and Hormones, 20, 493 (1962).
Schwarz, K., Vitamins and Hormones, 20, 463 (1962).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
STUYVESANT, V., JOLLEY, W. Anti-inflammatory Activity of d-α-Tocopherol (Vitamin E) and Linoleic Acid. Nature 216, 585–586 (1967). https://doi.org/10.1038/216585a0
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1038/216585a0
This article is cited by
-
Identification and detection of biofuel precursor cumene (benzene, (1-methylethyl)-) by spectroscopic and chromatographic techniques
Biomass Conversion and Biorefinery (2021)
-
Associations between dietary antioxidants intake and radiographic knee osteoarthritis
Clinical Rheumatology (2016)
-
Bolus injection of newly synthesized vitamin E derivative ETS-GS for the treatment of acute severe ulcerative colitis in a mouse model
International Journal of Colorectal Disease (2013)
-
The antiinflammatory moiety of sulfasalazine, 5-aminosalicylic acid, is a radical scavenger
Agents and Actions (1987)
-
Influence of 2,4-tetra-O-methyl-furfurylidene-sorbitol (MSF) on carrageenan-induced inflammation and anti-inflammatory and toxic effects of indomethacin in rats
Agents and Actions (1982)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
