Abstract
RECENT clinical reports1–3 have indicated that the combination of a neuroleptic and an antidepressant affords an added measure of therapeutic effectiveness in the treatment of certain mental disorders. In the course of our investigations on new psychoactive agents, we have found a compound (molindone hydrochloride, EN-1733A) with a profile in animals which predominantly resembles that of the neuroleptics and yet which contains some of the elements characteristic of antidepressants. Chemically, molindone (3 - ethyl - 6,7 - dihydro - 2 - methyl - 5-morpholino - methylindol - 4 - (5H) - one) is unlike any of the psycho therapeutic drugs at present available.
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RUBIN, A., YEN, H. & PFEFFER, M. Psychopharmacological Profile of Molindone. Nature 216, 578–579 (1967). https://doi.org/10.1038/216578a0
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DOI: https://doi.org/10.1038/216578a0
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