Abstract
In haemoglobin H disease, the rate of synthesis of the α-chains of haemoglobin is depressed, while that of the β-chains remains normal. It is shown that part of this excess of β-chains forms a pool capable of further participation in haemoglobin synthesis. The β-chains of haemoglobin H can exchange reversibly with those of haemoglobin A in the intact red cell.
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CLEGG, J., WEATHERALL, D. Haemoglobin Synthesis in α-Thalassaemia (Haemoglobin H Disease). Nature 215, 1241–1243 (1967). https://doi.org/10.1038/2151241a0
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DOI: https://doi.org/10.1038/2151241a0
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