Abstract
THE advent of drugs with the capacity to block the cardiac effects of catecholamines has provoked new interest in the study of the induction and blockade of rhythm disorders of the heart. Many of these new agents, such as pronethalol, depress disorders of the ventricular rhythm induced by both catecholamines and digitalis1–3. Initially, it was thought that depression of ventricular arrhythmia induced by digitalis was caused by the action of pronethalol in blocking the effect of catecholamines on the heart. It is now apparent, however, that the capacity of pronethalol to depress ventricular arrhythmia induced by digitalis is not related to the blockade of catecholamines4–6. Recently, Roberts and his colleagues6,7 have noted similar effects on digitalis-induced ventricular arrhythmia by pronethalol and β-TM10, an agent which prevents release of catecholamines from the adrenergic nerve terminals8, and have suggested that the anti-arrhythmic effect of pronethalol, like that of β-TM10, may be caused by an action of the drug on adrenergic nerve terminals.
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ROBERTS, J., LEVITT, B. & STANDAERT, F. Autonomic Nervous System and Control of Cardiac Rhythm. Nature 214, 912–913 (1967). https://doi.org/10.1038/214912a0
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DOI: https://doi.org/10.1038/214912a0
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