Abstract
EXPERIMENTS carried out on cytologically marked normal F1 recipients implanted with a thymus from a newborn donor of the parental type have shown that cellular traffic from the host to the thymus graft can take place1. Using neonatally thymectomized2–4 or thymectomized and irradiated5 recipients it has been possible to show that cells can also migrate from a thymus graft to the peripheral lymphoid tissue and that these may respond mitotically to immunological challenge6,7. In the situations in which thymic repopulation has been investigated in detail, it has always been possible for cells of thymic origin to react against some of the antigens of the F1 host. It is possible that this antigenic difference between the host and thymus graft might affect the repopulation process. In order to investigate this problem CBA/H recipients and cytologically marked CBA/H-T6T6 thymus graft donors have been used. There is no difference between these strains at the histocompatibility loci3. The cytological constitution of (a) the thymus graft at various times after grafting, (b) the spleen 30 days after thymus grafting and (c) the spleen following injection of antigen at 30 days has been determined.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Metcalf, D., and Wakonig-Vaartaja, R., Proc. Soc. Exp. Biol. and Med., 115, 731 (1964).
Miller, J. F. A. P., Ann. N. Y. Acad. Sci., 99, 340 (1962).
Harris, J. E., and Ford, C. E., Nature, 201, 884 (1964).
Dukor, P., Miller, J. F. A. P., House, W., and Allman, V., Transplantation, 3, 639 (1965).
Koller, P. C., Davies, A. J. S., Leuchars, E., and Wallis, V., in Proc. Bristol Lymphocyte Symp., No. 39, 342 (Edward Arnold, London, 1966).
Miller, J. F. A. P., de Burgh, P. M., Dukor, P., Grant, G., Allman, V., and House, W., Clin. and Exp. Immunol., 1, 61 (1966).
Davies, A. J. S., Leuchars, E., Wallis, V., and Koller, P. C., Transplantation, 4, 438 (1966).
Miller, J. F. A. P., Brit. J. Cancer, 14, 93 (1960).
Ford, C. E., and Hamerton, J. L., Stain Technol., 31, 247 (1956).
Rothfels, K., and Siminovitch, L., Stain Technol., 33, 73 (1958).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LEUCHARS, E., MORGAN, A., DAVIES, A. et al. Thymus Grafts in Thymectomized and Normal Mice. Nature 214, 801–802 (1967). https://doi.org/10.1038/214801a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/214801a0
This article is cited by
-
A Persistent Lymphoid Cell Population in the Thymus
Nature New Biology (1973)
-
Origin of PHA-responsive Cells in the Mouse Thymus after Treatment of the Animal with Hydrocortisone
Nature New Biology (1971)
-
Chimaerism after Introduction of Lymphocytes into Normal Mice
Nature (1970)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
