Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Genetics of Phenylketonuria: Heterozygosity for phenylketonuria

Abstract

The first article deals with the problem of using the response to injected phenylalanine to determine whether or not the subject is heterozygous for phenylketonuria. The second article suggests a third allele on the phenylketonuria locus, the corresponding enzyme having a higher affinity for phenylalanine than has the “normal” enzyme.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Hsia, D. Y.-Y., Driscoll, K. W., Troll, W., and Knox, W. E., Nature, 178, 1239 (1956).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Renwick, J. H., Lawler, S. D., and Cowie, V. A., Amer. J. Human Genet., 12, 287 (1960).

    CAS  Google Scholar 

  3. Wang, H. L., Morton, N. E., and Waisman, H. A., Amer. J. Human Genet., 13, 255 (1961).

    CAS  Google Scholar 

  4. Jervis, G. A., Clin. Chim. Acta, 5, 471 (1960); Anderson, J. A., Gravem, H., Ertel, R., and Fisch, R., J. Pediat., 61, 603 (1962).

    Article  CAS  PubMed  Google Scholar 

  5. Nelson, E., Nature, 205, 1024 (1965).

    Article  ADS  Google Scholar 

  6. Lippman, R. W., Shaw, K. N. F., Perry, T. L., Gutenstein, M., Redlich, D., Moore, P., and Walker, D., Clin. Res., 8, 142 (1960).

    Google Scholar 

  7. Goodwin, B. L., thesis, Univ, Oxford (1964).

  8. Woolf, L. I., Proc. N.A.T.O. Adv. Study Inst., “The Molecular Basis of Some Aspects of Mental Activity, 1, 249 (Academic Press, London, 1966).

    Google Scholar 

  9. Woolf, L. I., and Goodwin, B. L., Clin. Chem., 10, 146 (1964).

    Article  CAS  PubMed  Google Scholar 

  10. Udenfriend, S., and Cooper, J. R., J. Biol. Chem., 196, 227 (1952).

    CAS  PubMed  Google Scholar 

  11. Brodie, B. B., Axelrod, J., Soberman, R., and Levy, B. B., J. Biol. Chem., 179, 25 (1949).

    CAS  PubMed  Google Scholar 

  12. Goodwin, B. L., Cranston, W. I., and Woolf, L. I. (following article).

  13. Knox, W. E., Messinger, E. C., Amer. J. Human Genet., 10, 53 (1958).

    CAS  Google Scholar 

  14. Penrose, L. S., Ann. Eugenics, 16, 134 (1951).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

WOOLF, L., CRANSTON, W. & GOODWIN, B. Genetics of Phenylketonuria: Heterozygosity for phenylketonuria. Nature 213, 882–883 (1967). https://doi.org/10.1038/213882a0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/213882a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing