Abstract
KININS are polypeptides derived from naturally occurring plasma protein substrates (kininogen). The known kinins have been synthesized and are nonapeptides, decapeptides or undecapeptides1. Five principal pharmacological actions have been attributed to plasma kinins: stimulation of some smooth muscle, increase in vascular permeability, vasodilation, leucotaxis and induction of pain2. These actions are the cardinal manifestations of inflammation. It is not surprising, therefore, that kinins have been implicated among the mediators of the response of tissue to injury. The nonapeptide (bradykinin) can evoke an inflammatory response when applied to subcutaneous tissues3. Kinin levels increase at the site of inflammation caused by burns4, and during acute arthritis5.
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MELMON, K., CLINE, M. Interaction of Plasma Kinins and Granulocytes. Nature 213, 90–92 (1967). https://doi.org/10.1038/213090a0
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DOI: https://doi.org/10.1038/213090a0
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