Abstract
THE induction of immunological tolerance to soluble proteins can be achieved in rabbits by introducing a suitable dose into the foetus shortly before, or the infant shortly after, birth1. Yet in the case of the genetically determined IgG allotypes2,3 in rabbits, neither tolerance nor sensitization has been recorded, although the maternal IgG, which comprises virtually all the plasma IgG of the offspring at birth, being received by way of imbibition of amniotic fluid4 can contain an allotypic determinant not represented in the offspring's genotype5–7 and against which the offspring can afterwards be immunized. The purpose of this communication is to document this lack of tolerance, although we cannot at present provide any explanation for it.
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GELL, P., KELUS, A. Lack of Natural Tolerance to Allotypic γ-Globulins in Rabbits. Nature 211, 766–767 (1966). https://doi.org/10.1038/211766a0
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DOI: https://doi.org/10.1038/211766a0
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