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Thyrocalcitonin: Failure to demonstrate a Parathyroid Releasing Factor

Nature volume 211, pages 1319–1320 (1966)Cite this article

Abstract

THYROCALCITONIN1 is the plasma calcium lowering hormone secreted by the thyroid in response to a high blood calcium stimulus2–5. The hormone is identical to calcitonin which was originally thought to be of parathyroid origin6. The possible interrelated roles of the thyroid and parathyroids have been studied by Gittes and Irvin7. Their results suggested that a parathyroid factor might be responsible for the release of the hormone from the thyroid: parathyroidectomized rats were found less able to counteract the hypercalcaemia induced by exogenous parathyroid hormone than intact rats. The studies of these workers have been repeated, in part, to investigate the possibility of a parathyroid releasing factor by assessing the ability of parathyroidectomized animals to withstand an intraperitoneal challenge of calcium chloride.

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  1. Department of Chemical Pathology, Postgraduate Medical School, London, W.12.

    G. V. FOSTER

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  1. G. V. FOSTER
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FOSTER, G. Thyrocalcitonin: Failure to demonstrate a Parathyroid Releasing Factor. Nature 211, 1319–1320 (1966). https://doi.org/10.1038/2111319a0

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