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Effect of Propranolol on the Peripheral Vascular Bed

Nature volume 209, pages 923–924 (1966)Cite this article

Abstract

A NEWLY synthesized compound, propranolol, was found to be a very potent, β-receptor adrenergic blocking agent1. Since the drug blocks the vasodilator (β-receptor stimulating) effects of catecholamines without affecting the vasoconstrictor (α-receptor stimulating) property, propranolol should be expected to cause the vasocon-striction of the peripheral vessels. However, Prichard and Gillam2 recently found that propranolol lowered arterial blood pressure significantly in hypertensive patients. The present investigation was undertaken to examine the effect of propranolol on the peripheral vascular bed.

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References

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Authors and Affiliations

  1. Department of Pharmacology, University of Oklahoma, Oklahoma City

    J. NAKANO & T. KUSAKARI

Authors
  1. J. NAKANO
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  2. T. KUSAKARI
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NAKANO, J., KUSAKARI, T. Effect of Propranolol on the Peripheral Vascular Bed. Nature 209, 923–924 (1966). https://doi.org/10.1038/209923a0

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