Abstract
IT has been known since the work of Stetten and Boxer1 that glucose is rapidly converted into lipid in tissues of well-fed animals, while lipogenesis is greatly depressed in tissues of diabetic animals. Neither liver slices nor adipose tissue from diabetic rats can convert glucose labelled with carbon-14 into fatty acids2,3. The rate of synthesis of long-chain fatty acids from glucose by isolated tissues removed from normal animals is actually more rapid in adipose tissue than in liver, whether expressed on a wet weight or a protein basis4. The relatively high rate of lipogenesis in adipose tissue, coupled with its abundance, has suggested that this tissue may be of predominant importance in the in vivo synthesis of lipid4,5. While there has been extensive work on the enzymatic lesions in fatty acid synthesis in the livers of alloxan-diabetic rats, adipose tissue has not been so widely studied5,6.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Stetten, jun., D., and Boxer, G. E., J. Biol. Chem., 156, 271 (1944).
Chernick, S. S., Chaikoff, I. L., Masoro, E. J., and Isaeff, E., J. Biol. Chem., 186, 527 (1950).
Hausberger, F. X., Milstein, S. W., and Rutman, R. J., J. Biol. Chem., 208, 431 (1954).
Fritz, I. B., Physiol. Revs., 41, 52 (1961).
Masoro, E. J., J. Lipid Res., 3, 149 (1962).
Vagelos, P. R., Ann. Revs. Biochem., 33, 139 (1964).
Lowenstein, J. M., in Oxygen in the Animal Organism, Intern. Union Biol. Symp. Ser., 31, 163 (Pergamon Press, 1964).
Srere, P. A., Nature, 205, 766 (1965).
Kornacker, M. S., and Lowenstein, J. M., Biochim. Biophys. Acta, 84, 490 (1964).
Kornacker, M. S., and Lowenstein, J. M., Biochem. J., 94, 209 (1965).
Wieland, O., 4e Congrès de la Fédération internationale du Diabéte, Génève, 1, 131 (Editions Médecine et Hygiène, Génève, 1961).
Martin, D. B., and Vagelos, P. R., J. Biol. Chem., 237, 1797 (1962).
Passonneau, J. V., and Lowry, O. H., Biochem. Biophys. Res. Comm., 13, 372 (1963).
Howard, C. F., and Lowenstein, J. M., Biochim. Biophys. Acta, 84, 228 (1964).
Tzuz, R., Tal, E., and Shapiro, B., Biochim. Biophys. Acta, 84, 18 (1964).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BROWN, J., MCLEAN, P. Effect of Alloxan-Diabetes on the Activity of Citrate Cleavage Enzyme in Adipose Tissue. Nature 207, 407–408 (1965). https://doi.org/10.1038/207407a0
Issue Date:
DOI: https://doi.org/10.1038/207407a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
