Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Lathyrism and 7,12-Dimethylbenzanthracene-induced Carcinoma in the Rat

Nature volume 207, pages 310–311 (1965)Cite this article

Abstract

THE lathyritic agent, β-amino-poprionitrile (BAPN), reduces the tensile strength of mesenchyrnal tissue and modifies the collagen content1,2. Since local tissue factors are believed to be of importance in tumour growth, BAPN was administered to rats in which tumours were induced by a polycyclic hydrocarbon. 7,12-Dimethylbenzanthracene (DMBA) was used because it regularly induces mammary carcinoma in young female Sprague–Dawley rats. The strain of rat, the age, and the hormonal status are important factors in the induction of mammary carcinoma4.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Gardner, A. F., Amer. J. Clin. Nut., 7, 213 (1959).

    Article  CAS  Google Scholar 

  2. Hurley, J. V., and Ham, K. N., Brit. J. Exp. Path., 40, 216 (1959).

    CAS  PubMed  Google Scholar 

  3. Huggins, C., et al., Ann. Surg., 154 Suppl., 315 (1961).

    Article  Google Scholar 

  4. Boyland, E., and Sydnor, K. L., Brit. J. Cancer, 16, 731 (1962).

    Article  CAS  Google Scholar 

  5. Engel, L. L. et al., J. Biol. Chem., 185, 255 (1950).

    CAS  PubMed  Google Scholar 

  6. Brown, J. B., Biochem. J., 60, 185 (1955).

    Article  CAS  Google Scholar 

  7. Karpas, C. M., and Madden, R. E., Proc. Amer. Assoc. Canc. Res., 5, 34 (1964).

    Google Scholar 

  8. Wong, T. W., et al., Canc. Res., 22, 1053 (1962).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Research, Chicago Wesley Memorial Hospital,

    JOHN S. SCHWEPPE, RENATO BASERGA, LINDA HARRIS & R. A. JUNGMANN

  2. Department of Pathology, Northwestern University Medical School, Chicago, Illinois

    JOHN S. SCHWEPPE, RENATO BASERGA, LINDA HARRIS & R. A. JUNGMANN

Authors
  1. JOHN S. SCHWEPPE
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. RENATO BASERGA
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. LINDA HARRIS
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. A. JUNGMANN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

SCHWEPPE, J., BASERGA, R., HARRIS, L. et al. Lathyrism and 7,12-Dimethylbenzanthracene-induced Carcinoma in the Rat. Nature 207, 310–311 (1965). https://doi.org/10.1038/207310b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/207310b0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing