Abstract
D-PENICILLAMINE is used in the treatment of Wilson's disease1 and in cases of lead poisoning2. Recently, Crawhall et al.3 reported that the administration of D-penicillamine to two cystinuric patients resulted in a marked fall in the excretion of cystine in urine. This was believed to be due to disulphide exchange resulting in the formation of the mixed disulphide of D-penicillamine and cysteine. It has therefore been suggested that D-penicillamine might prove useful in the management of this condition.
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References
Walshe, J. M., Amer. J. Med., 21, 487 (1956).
Goldberg, A., Smith, J. A., and Lochhead, A. C., Brit. Med. J., i, 1270 (1963)
Crawhall, J. C., Scowen, E. F., and Watts, R. W. E., Brit. Med. J., i, 588 (1963).
Kuchinskas, E. J., and Du Vigneaud, V., Arch. Biochem. Biophys., 66, 1 (1957).
Kuchinskas, E. J., Horvath, A., and Du Vigneaud, V., Arch. Biochem. Biophys., 68, 69 (1957).
Du Vigneaud, V., Kuchinskas, E. J., and Horvath, A., Arch. Biochem. Biophys., 69, 130 (1957).
Heddle, J. G., McHenry, E. W., and Beaton, G. H., Canad. J. Biochem. Physiol., 41, 1215 (1963).
Ueda, K., Akedo, H., and Suda, M., J. Biochem. (Tokyo), 48, 584 (1960).
Korbitz, B. C., Price, J. M., and Brown, R. R., J. Nutrition, 80, 55 (1963).
Partridge, S. M., Nature, 158, 270 (1946).
Dalgliesh, C. E., Biochem. J., 64, 481 (1956).
Wachstein, M., and Gudaitis, A., Amer. J. Clin. Path., 22, 652 (1952).
Dalgliesh, C. E., Biochem. J., 52, 3 (1952).
Lepkovsky, S., Roboz, E., and Haagen-Smit, A. J., J. Biol. Chem., 149, 195 (1943).
Weber, F., and Wiss, O., Hoppe-Seyler's Z. physiol. Chem., 331, 124 (1963).
Evered, D. F., Brit. Med. J., 2, 120 (1963).
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ASATOOR, A. Pyridoxine Deficiency in the Rat produced by D-Penicillamine. Nature 203, 1382–1383 (1964). https://doi.org/10.1038/2031382b0
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DOI: https://doi.org/10.1038/2031382b0
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