Abstract
THYMECTOMY in the new-born1,2 or in the adult irradiated mouse3 leads to a long-lasting suppression of the ability to respond to primary antigenic challenge. It has been shown in both instances that thymus grafting is effective in restoring immunological competence2,4,5 and, furthermore, when using a cytologically marked thymic graft, it has been possible to detect cells derived from the graft in the spleen and lymph nodes2,5. It has, therefore, been suggested5 that it may be these donor cells which are directly responsible for the recovery of the primary immune response in thymus-grafted animals.
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Miller, J. F. A. P., Lancet, ii, 748 (1961).
Miller, J. F. A. P., Proc. Roy. Soc., B, 156, 415 (1962).
Miller, J. F. A. P., Doak, S. M. A., and Cross, A. M., Proc. Soc. Exp. Biol. Med., 112, 785 (1963).
Martinez, C., Dalmasso, A. P., and Good, R. A., Ann. N.Y. Acad. Sci., 113, 933 (1964).
Leuchars, E., Cross, A. M., and Dukor, P., Transplantation (in the press).
Miller, J. F. A. P., Brit. J. Cancer, 14, 93 (1960).
Ford, C. E., and Hamerton, J. L., Stain Technol., 31, 247 (1956).
Rothfels, K. H., and Siminovitch, L., Stain Technol., 33, 73 (1958).
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LEUCHARS, E., CROSS, A., DAVIES, A. et al. A Cellular Component of Thymic Function. Nature 203, 1189 (1964). https://doi.org/10.1038/2031189a0
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DOI: https://doi.org/10.1038/2031189a0
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