Abstract
INTRAPERITONEAL administration of L-methionine1 as well as incorporation of DL-methionine2 and DL-ethionine3 in the purified diets of rats resulted in increased activity of rat liver cystathionase (‘soluble’ cysteine desulphydrase). Recently, I have also observed4 that one injection of L-ethionine likewise caused, in 4 h, significant increase in the activity of the enzyme in rat liver. In an effort to determine the chemical basis for the effects of these amino-acids, analyses of the free amino-acids of the liver of control (non-treated) as well as of ethionine and methionine-treated rats were carried out.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Chatagner, F., and Trautmann, O., Nature, 194, 1281 (1962).
Trautmann, O., and Chatagner, F., Bull. Soc. Chim. Biol., 46, 129 (1964).
Chatagner, F., and Trautmann, O., Nature, 200, 75 (1963).
Trautmann, O., and Chatagner, F. (unpublished results).
Awapara, J., Arch. Biochem., 19, 172 (1948).
Piez, K. A., and Morris, L., Anal. Biochem., 1, 187 (1960).
Hamilton, P. B., Ann. N.Y. Acad. Sci., 102, 55 (1962).
Matsuo, Y., and Greenberg, D. M., J. Biol. Chem., 234, 516 (1959).
Matsuo, Y., and Greenberg, D. M., J. Biol. Chem., 215, 547 (1955).
Stekol, J. A., Weiss, S., and Somerville, C., Arch. Biochem. Biophys., 100, 86 (1963).
Kun, E., in Metabolic Pathways, edited by Greenberg, D. M., 2, 237 (Academic Press, New York, 1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
CHATAGNER, F. Occurrence of Homoserine in the Liver of Ethionine- or Methionine-treated Rats. Nature 203, 1177–1178 (1964). https://doi.org/10.1038/2031177b0
Issue Date:
DOI: https://doi.org/10.1038/2031177b0
This article is cited by
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.