Abstract
INVESTIGATIONS carried out by Helyer and Howie on a hybrid strain of mice derived by crossing the NZB/BL and NZW strains show that these animals died of renal failure within 8–10 months1. The renal lesions in these animals closely resembled those seen in human lupus nephritis. Using conventional microscopical techniques marked glomerular changes, including fibrinoid necrosis, thickening of the basement membrane and wire-loop formation were demonstrated.
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AARONS, I. Renal Immunofluorescence in NZB/NZW Mice. Nature 203, 1080–1081 (1964). https://doi.org/10.1038/2031080a0
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DOI: https://doi.org/10.1038/2031080a0
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