Abstract
EARLY experiments by Billingham and Brent1 have demonstrated that mice of the A strain injected at birth with spleen cells from either (AU × CBA) or (C57BL/6 × CBA) F1 hybrids elicited tolerance of CBA strain skin grafts but not of the C57BL/6, AU or F1 hybrid tissue. Billingham and Silvers2 and Lustgraaf et al.3 have made similar observations in female mice of the C57BL strain injected at birth with allogeneic cells derived from A strain males. Under these conditions the injected females did not become tolerant of allogeneic A strain grafts but did accept syngeneic C57BL male skin grafts. This divided tolerance for only maleness was called by Lustgraaf et al.8 “split tolerance”, a term which has been extended to include the hybrid to pure strain system1.
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References
Billingham, R. E., and Brent, L., Phil. Trans. Roy. Soc. B., 242, 439 (1959).
Billingham, R. E., and Silvers, W. K., J. Immunol., 85, 14 (1960).
Lustgraaf, E. C., Fuson, R. B., and Eichwald, E. J., Transpl. Bull., 26, 145 (1960).
Brent, L., and Courtenay, T. H., in Mechanism of Immunological Tolerance, edit. by Hasek, M., Lengerova, A., and Vojtiskova, M., 113 (Czechoslovak Acad. Sci., 1962).
Martinez, C., Smith, J. M., Blaese, M., and Good, R. A., J. Exp. Med., 118, 743 (1963).
Martinez, C., Smith, J. M., Aust, J. B., and Good, R. A., Proc. Soc. Exp. Biol. and Med., 97, 736 (1958).
Kelly, W. D., Smith, J. M., Martinez, C., and Good, R. A., Proc. Soc. Exp. Biol. and Med., 115, 8 (1964).
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MARTINEZ, C., SMITH, J. Split Tolerance. Nature 202, 508–509 (1964). https://doi.org/10.1038/202508a0
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DOI: https://doi.org/10.1038/202508a0
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