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Adult Tolerance induced by 6-Methyl Mercaptopurine to a Canine Renal Homograft

Nature volume 198, pages 706–707 (1963)Cite this article

Abstract

ADULT acquired tolerance for an organ homotransplant can be achieved between unrelated animals only if the immunological mechanisms of the transplantation reaction are reduced or suppressed. Antimetabolites have been used to extend renal homograft survival for prolonged periods, but once the drug has been withdrawn, rejection has been the immediate result. In a further attempt to prolong canine renal homograft survival, the effect of 6-methyl mercaptopurine (6-methyl MP) was investigated. A preliminary report of this work has been published1.

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Authors and Affiliations

  1. Surgical Service, Veterans Administration Hospital and Department of Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee

    CHARLES F. ZUKOSKI & JAMES M. CALLAWAY

Authors
  1. CHARLES F. ZUKOSKI
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  2. JAMES M. CALLAWAY
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ZUKOSKI, C., CALLAWAY, J. Adult Tolerance induced by 6-Methyl Mercaptopurine to a Canine Renal Homograft. Nature 198, 706–707 (1963). https://doi.org/10.1038/198706a0

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