Abstract
Based on preclinical studies, combined kidney and hematopoietic cell transplantation was performed on fully HLA matched and haplotype matched patients at the Stanford University Medical Center. The object of the studies was to induce mixed chimerism, immune tolerance, and complete immunosuppressive drug withdrawal. Tolerance, persistent mixed chimerism, and complete withdrawal was achieved in the majority of fully matched patients. Persistent mixed chimerism and partial withdrawal has been achieved in the haplotype matched patients at present.
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Funding
The research was supported by grants from their National Institutes of Health (P01HL075462 and R01 AI 1085024), and a grant from the California Institute of Regenerative Medicine (CLIN2–09439). Publication of this supplement was sponsored by Gilead Sciences Europe Ltd, Cell Source, Inc., The Chorafas Institute for Scientific Exchange of the Weizmann Institute of Science, Kiadis Pharma, Miltenyi Biotec, Celgene, Centro Servizi Congressuali, Almog Diagnostic.
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SS and RL receive consulting fees and owns equity in Medeor Therapeutics Inc., and receive royalties payments on patents held by their employer.
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Lowsky, R., Strober, S. Combined kidney and hematopoeitic cell transplantation to induce mixed chimerism and tolerance. Bone Marrow Transplant 54 (Suppl 2), 793–797 (2019). https://doi.org/10.1038/s41409-019-0603-4
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DOI: https://doi.org/10.1038/s41409-019-0603-4
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