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In vivo Anti-Tumour Activity of Ethyl Heptyloxyacetate against Ehrlich Ascites Cells

Nature volume 198, pages 384–385 (1963)Cite this article

Abstract

PREVIOUS investigations1–5 have shown that whole royal jelly, a fraction from royal jelly (10-hydroxy-2-decenoic acid) and certain closely related dicarboxylic acids, some of which are also found in royal jelly6, will inhibit the development of transplantable AKR leukæmia and ascites tumours when added in vitro just prior to transfer. This activity was associated mainly with 9-and 10-carbon straight-chain monocarboxylic acids, particularly decanoic acid in the ethyl ester form. These compounds showed no activity in vivo.

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Authors and Affiliations

  1. Department of Apiculture,

    GORDON F. TOWNSEND

  2. Department of Chemistry, Ontario Agricultural College, Guelph, Ontario

    WILLIAM H. BROWN & ETHEL E. FELAUER

Authors
  1. GORDON F. TOWNSEND
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  2. WILLIAM H. BROWN
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  3. ETHEL E. FELAUER
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TOWNSEND, G., BROWN, W. & FELAUER, E. In vivo Anti-Tumour Activity of Ethyl Heptyloxyacetate against Ehrlich Ascites Cells. Nature 198, 384–385 (1963). https://doi.org/10.1038/198384b0

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