Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Yohimbine as an Autonomic Test Drug

Nature volume 193, pages 1313–1314 (1962)Cite this article

Abstract

YOHIMBINE in fairly high doses (2–7 mgm./kgm.) exerts adrenolytic effects and is sympatholytic for salivary reactions in animals1–5. Higher doses (28 mgm./kgm.) produce sympatholysis of nictitating membrane retraction, while even more is required for sympatholysis of mydriatic action2,3.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Raymond-Hamet, C. R., C.R. Acad. Sci. Paris, 180, 2074 (1925).

    CAS  Google Scholar 

  2. Barry, D. T., Arch. Intern. Pharmacodyn. et Therap., 55, 385 (1937).

    CAS  Google Scholar 

  3. Yonkman, F. F., Stilwell, D., and Jeremias, R., J. Pharmacol. and Exp. Therap., 81, 111 (1944).

    Google Scholar 

  4. Bovet, D., and Bovet-Nitti, F., Médicaments du Système Nerveux Végétatif (Karger, Basel and New York, 1948).

    Google Scholar 

  5. Nickerson, M., Pharmacol. Rev., 1, 27 (1949).

    Google Scholar 

  6. Kendall, M. G., Rank Correlation Methods (Griffin, London, 1948).

    MATH  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Schizophrenia and Psychopharmacology Joint Research Project, University of Michigan/Ypsilanti State Hospital, Box A, Ypsilanti, Michigan

    GUNNAR HOLMBERG, SAMUEL GERSHON & LLOYD H. BECK

Authors
  1. GUNNAR HOLMBERG
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. SAMUEL GERSHON
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. LLOYD H. BECK
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

HOLMBERG, G., GERSHON, S. & BECK, L. Yohimbine as an Autonomic Test Drug. Nature 193, 1313–1314 (1962). https://doi.org/10.1038/1931313b0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/1931313b0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing