Abstract
The recent discovery of the human counterpart of the hairless mouse phenotype1 has helped our understanding of the molecular genetics of hair growth. But there are no reports of a defect in the human homologue of the best known of the ‘bald’ mouse phenotypes, the nude mouse2. This may be because affected individuals are so gravely ill from the accompanying immunodeficiency that their baldness goes unnoticed. We have carried out a genetic analysis that reveals a human homologue of the nude mouse.
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References
Ahmad, W. et al. Science 279, 720–724 (1998).
Flanagan, S. P. Genet. Res. 8, 295–309 (1966).
Nehls, M., Pfeifer, D., Schorpp, M., Hedrich, H. & Boehm, T. Nature 372, 103–107 (1994).
Pignata, C. et al. Am. J. Med. Genet. 65, 167–170 (1996).
Schorpp, M., Hoffmann, M., Dear, T. N. & Boehm, T. Immunogenetics 46, 509–515 (1997).
Kaufmann, E. & Knöchel, W. Mech. Dev. 57, 3–20 (1996).
Nehls, M. et al. Science 272, 886–889 (1996).
Brissette, J. L., Li, J., Kamimura, J., Lee, D. & Dotto, G. P. Genes Dev. 10, 2212–2221 (1996).
Muller-Hermelink, H. K., Wilisch, A., Schultz, A. & Marx, A. Arch. Histol. Cytol. 60, 9–28 (1997).
Fischer, A. et al. Annu. Rev. Immunol. 15, 93–124 (1997).
Köpf-Maier, P. et al. Acta Anat. 139, 178–190 (1990).
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Frank, J., Pignata, C., Panteleyev, A. et al. Exposing the human nude phenotype. Nature 398, 473–474 (1999). https://doi.org/10.1038/18997
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DOI: https://doi.org/10.1038/18997
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