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Dose–Response Relationship in Radiation Carcinogenesis

Abstract

THE question whether the dose–response relationship for neoplasia induced by ionizing radiations is linear or non-linear, and with or without a threshold dose, is one of the most important problems in both basic and applied radiobiology1.

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References

  1. Report of the United Nations Scientific Committee on the Efects of Atomic Radiation (New York, 1958).

  2. Huxley, “Biological Aspects of Cancer” (Allen and Unwin, London, 1958). Boyland, ed., Brit. Med. Bull., 14, No. 2 (1958). Strong, ed., Ann. New York Acad. Sci., 71, Art. 6 (1958). Wolstenholme and O'Connor, ed., “CIBA Fondation Symposium on Carcinogenesis. Mechanisms of Action” (Churchill, London, 1959). Levan, Statens Naturvetenskapliga Forskningsråds Åsbok, 12, 212 (Stockholm, 1959). Bayreuther, K., Nature, 186, 6 (1960).

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  3. Arley and Iversen, Acta Path. Microbiol. Scand., 33, 133 (1953), see p. 143.

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  5. Bacq and Alexander, “Fundamentals of Radiobiology” (Butterworth, London, 1955); see especially Chapter 11.

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ARLEY, N., EKER, R. Dose–Response Relationship in Radiation Carcinogenesis. Nature 189, 151–152 (1961). https://doi.org/10.1038/189151a0

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